Featured
-
-
Article
| Open AccessStatine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro)
- Pedro Henrique R. de A. Azevedo
- , Priscila G. Camargo
- & Estela Maris F. Muri
-
Article
| Open AccessDesign, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents
- Payal Kamboj
- , Anjali
- & Mohd. Amir
-
Article
| Open AccessDP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
- , Michaela Ulrich
- & Moritz Bünemann
-
Article
| Open AccessOvercoming radioresistance of breast cancer cells with MAP4K4 inhibitors
- Yun-Suk Kwon
- , Min-Gu Lee
- & Soyoung Kim
-
Article
| Open AccessNetwork pharmacology analysis and experimental validation to explore the mechanism of kaempferol in the treatment of osteoporosis
- Qi Dong
- , Guoxia Ren
- & Dingjun Hao
-
Article
| Open AccessLC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme
- Noha Mokhtar Abd-El-Aziz
- , Mohamed Saeed Hifnawy
- & Inas Youssef Younis
-
Article
| Open AccessN-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
- Ji Eun Kim
- , Phatcharaporn Budluang
- & Young-Hwa Chung
-
Article
| Open Access5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release
- Lina Bukowski
- , Markus Emanuel Strøm
- & Steffen Sinning
-
Article
| Open AccessDevelopment of extended pharmacokinetic models for propofol based on measured blood and brain concentrations
- Masayoshi Kawata
- , Atsushi Yonezawa
- & Yoshiki Arakawa
-
Article
| Open AccessDesert date seed extract-loaded chitosan nanoparticles ameliorate hyperglycemia and insulin deficiency through the reduction in oxidative stress and inflammation
- Alyaa Farid
- , Alaa Ahmed
- & Gehan Safwat
-
Article
| Open AccessBioinformatics analysis and experimental validation revealed that Paeoniflorigenone effectively mitigates cerebral ischemic stroke by suppressing oxidative stress and inflammation
- Zhiyan Wu
- & Xingrong Tang
-
Article
| Open AccessEvaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control
- Harish Kumar Shah
- , Vaishnavi Srinivasan
- & Vijesh Sreedhar Kuttiatt
-
Article
| Open AccessTranscriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells
- Jiraporn Jantaravinid
- , Napatara Tirawanchai
- & Pornanong Aramwit
-
Article
| Open AccessApomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors
- Akihiko Miyauchi
- , Chika Watanabe
- & Hitoshi Osaka
-
Article
| Open AccessMortality after major bleeding in Asian atrial fibrillation patients receiving different direct oral anticoagulants: a nationwide, propensity score study
- Jiun-Hao Yu
- , Pei-Ru Li
- & Lai-Chu See
-
Article
| Open AccessStudy of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway
- Chunyu Chen
- , Xiaoxing Liu
- & Fan Yi
-
Article
| Open AccessRepeated microdoses of LSD do not alter anxiety or boldness in zebrafish
- Ethan V. Hagen
- , Melike Schalomon
- & Trevor J. Hamilton
-
Article
| Open AccessForensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation
- Paul N. Newton
- , Lesley A. Chesson
- & Thure E. Cerling
-
Article
| Open AccessRevealing the pharmacological effects of Remodelin against osteosarcoma based on network pharmacology, acRIP-seq and experimental validation
- Jia Gao
- , Peili Xu
- & Lei Fan
-
Article
| Open AccessPsychedelics and sexual functioning: a mixed-methods study
- Tommaso Barba
- , Hannes Kettner
- & Bruna Giribaldi
-
Article
| Open AccessFunctional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study
- Sophia Armand
- , Christelle Langley
- & Patrick MacDonald Fisher
-
Article
| Open AccessIntegrating transcriptomics and metabolomics to elucidate the mechanism by which taurine protects against DOX-induced depression
- Yanan Li
- , Luxi Li
- & Pei Jiang
-
Article
| Open AccessAerosolized delivery of ESKAPE pathogens for murine pneumonia models
- Katharina Rox
- & Eva Medina
-
Article
| Open AccessIn vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- Shaimaa E. Diab
- , Nourhan A. Tayea
- & Zakia A. Olama
-
Article
| Open AccessKv3.4 regulates cell migration and invasion through TGF-β-induced epithelial–mesenchymal transition in A549 cells
- Hun Ju Sim
- , Mi Ri Kim
- & So Yeong Lee
-
Article
| Open AccessDose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice
- Rachelle Driscoll
- , Lucas Hampton
- & Andreas Weihofen
-
Article
| Open AccessNeuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model
- Sofia V. Salvatore
- , Ma. Xenia G. Ilagan
- & Steven Mennerick
-
Article
| Open AccessEstablishment of a forward primers-superposed amplification analysis for accurate aspirin pharmacogenomic measurement
- Chun-Yan Li
- , Ping Yang
- & Wen-Jun Lan
-
Article
| Open AccessImpact of maternal first trimester treatment regimen on the outcome of valproate exposed pregnancies: an observational Embryotox cohort study
- Anne-Katrin Fietz
- , Marlies Onken
- & Katarina Dathe
-
Article
| Open AccessSophocarpine alleviates doxorubicin-induced heart injury by suppressing oxidative stress and apoptosis
- Hong-jin Zhang
- , Yang Fu
- & Yi-Fei Dong
-
Article
| Open AccessExploring the impact of naltrexone on the THBS1/eNOS/NO pathway in osteoporotic bile duct-ligated rats
- Seyed Reza Hosseini-Fard
- , Shahroo Etemad-Moghadam
- & Abolfazl Golestani
-
Article
| Open AccessSemaglutide reduces tumor burden in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH-HCC with advanced fibrosis
- Henrik H. Hansen
- , Susanne Pors
- & Michael Feigh
-
Article
| Open AccessRandomized phase II study of preoperative afatinib in untreated head and neck cancers: predictive and pharmacodynamic biomarkers of activity
- Grégoire Marret
- , Stéphane Temam
- & Christophe Le Tourneau
-
Article
| Open AccessChicoric acid ameliorates LPS-induced inflammatory injury in bovine lamellar keratinocytes by modulating the TLR4/MAPK/NF-κB signaling pathway
- Xiang Lan
- , Dongdong Qi
- & Jiantao Zhang
-
Article
| Open AccessCharacterization of cannabinoid plasma concentration, maternal health, and cytokine levels in a rat model of prenatal Cannabis smoke exposure
- Tallan Black
- , Sarah L. Baccetto
- & Robert B. Laprairie
-
Article
| Open Access1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors
- Maurício T. Tavares
- , Arne Krüger
- & Roberto Parise-Filho
-
Article
| Open AccessEfficacy and safety of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists in augmentation with selective serotonin reuptake inhibitors (SSRIs) in the treatment of moderate to severe obsessive–compulsive disorder: a systematic review and meta-analysis of randomized clinical trials
- Negin Eissazade
- , Hesam Mosavari
- & Mohammadreza Shalbafan
-
Article
| Open AccessAbuse liability of two electronic nicotine delivery systems compared with combustible cigarettes and nicotine gum from an open-label randomized crossover study
- Chris Campbell
- , Tao Jin
- & Sarah Baxter
-
Article
| Open AccessEffects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors
- Soichiro Ide
- , Toshitake Hirai
- & Kazutaka Ikeda
-
Article
| Open AccessAdenosine A1 receptors of the medullary solitary tract arbitrate the nicotine counteraction of neuroinflammation and cardiovascular dysfunction in septic rats
- Amany E. El-Naggar
- , Mai M. Helmy
- & Mahmoud M. El-Mas
-
Article
| Open AccessA critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy
- Alena Randáková
- , Dominik Nelic
- & Jan Jakubík
-
Article
| Open AccessThe suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats
- Sherien A. Abdelhady
- , Mennatallah A. Ali
- & Mahmoud M. El-Mas
-
Article
| Open AccessPsilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences
- Nathalie M. Rieser
- , Ladina P. Gubser
- & Katrin H. Preller
-
Article
| Open AccessNetwork pharmacology and experimental verification of the potential mechanism of Er-Xian decoction in aplastic anemia
- Mei Ye
- , Guangxian Liu
- & Zeli Gao
-
Article
| Open AccessMercaptonicotinic acid activated thiolated chitosan (MNA-TG-chitosan) to enable peptide oral delivery by opening cell tight junctions and enhancing transepithelial transport
- Anubhav Pratap-Singh
- , Yigong Guo
- & Anika Singh
-
Article
| Open AccessA memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration
- Lihong Cheng
- , Mitsuru Tanaka
- & Toshiro Matsui
-
Article
| Open AccessThe anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis
- Erik Márk Orján
- , Eszter Sára Kormányos
- & Lóránd Kiss
-
Article
| Open AccessReproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19
- Rob C. van Wijk
- , Laurynas Mockeliunas
- & Ulrika S. H. Simonsson
-
Article
| Open AccessRecovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection
- Ayami Watanabe
- , Ami Nakajima
- & Mitsunori Shiroishi