Drug discovery

Definition

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.

Featured

Latest Research and Reviews

  • Reviews |

    Patients receiving anticancer therapies based on immune-checkpoint blockade (ICB) often experience clinical benefits from such treatments, but unconventional patterns of response can be observed, emphasizing the importance of using a specific approach to evaluating responses to immunotherapy. Herein, the authors review the biological mechanisms underlying the response patterns associated with ICB, describe strategies for the assessments of such responses, and highlight the ongoing efforts to identify biomarkers to guide treatment with ICB.

    • Mizuki Nishino
    • , Nikhil H. Ramaiya
    • , Hiroto Hatabu
    •  & F. Stephen Hodi
  • Research |

    Nanoparticles can be utilized to capture tumour antigens and improve their presentation, which in turn improves the efficacy of cancer immunotherapy.

    • Yuanzeng Min
    • , Kyle C. Roche
    • , Shaomin Tian
    • , Michael J. Eblan
    • , Karen P. McKinnon
    • , Joseph M. Caster
    • , Shengjie Chai
    • , Laura E. Herring
    • , Longzhen Zhang
    • , Tian Zhang
    • , Joseph M. DeSimone
    • , Joel E. Tepper
    • , Benjamin G. Vincent
    • , Jonathan S. Serody
    •  & Andrew Z. Wang
  • Research |

    Damian Smedley and colleagues report the phenotypic characterization of the first 3,328 genes by the International Mouse Phenotyping Consortium. They develop new mouse models based on genes known to be associated with human mendelian diseases and identify potential disease-associated genes with little or no previous functional annotation.

    • Terrence F Meehan
    • , Nathalie Conte
    • , David B West
    • , Julius O Jacobsen
    • , Jeremy Mason
    • , Jonathan Warren
    • , Chao-Kung Chen
    • , Ilinca Tudose
    • , Mike Relac
    • , Peter Matthews
    • , Natasha Karp
    • , Luis Santos
    • , Tanja Fiegel
    • , Natalie Ring
    • , Henrik Westerberg
    • , Simon Greenaway
    • , Duncan Sneddon
    • , Hugh Morgan
    • , Gemma F Codner
    • , Michelle E Stewart
    • , James Brown
    • , Neil Horner
    • , The International Mouse Phenotyping Consortium
    • , Melissa Haendel
    • , Nicole Washington
    • , Christopher J Mungall
    • , Corey L Reynolds
    • , Juan Gallegos
    • , Valerie Gailus-Durner
    • , Tania Sorg
    • , Guillaume Pavlovic
    • , Lynette R Bower
    • , Mark Moore
    • , Iva Morse
    • , Xiang Gao
    • , Glauco P Tocchini-Valentini
    • , Yuichi Obata
    • , Soo Young Cho
    • , Je Kyung Seong
    • , John Seavitt
    • , Arthur L Beaudet
    • , Mary E Dickinson
    • , Yann Herault
    • , Wolfgang Wurst
    • , Martin Hrabe de Angelis
    • , K C Kent Lloyd
    • , Ann M Flenniken
    • , Lauryl M J Nutter
    • , Susan Newbigging
    • , Colin McKerlie
    • , Monica J Justice
    • , Stephen A Murray
    • , Karen L Svenson
    • , Robert E Braun
    • , Jacqueline K White
    • , Allan Bradley
    • , Paul Flicek
    • , Sara Wells
    • , William C Skarnes
    • , David J Adams
    • , Helen Parkinson
    • , Ann-Marie Mallon
    • , Steve D M Brown
    •  & Damian Smedley
  • Reviews |

    The authors review the concept of synthetic lethality — when the perturbation of one of two genes alone is viable, but the perturbation of both genes simultaneously results in the loss of viability — from model organisms to human cancers, and discuss how genetic interactions can be exploited for the identification of new drug targets in cancer.

    • Nigel J. O'Neil
    • , Melanie L. Bailey
    •  & Philip Hieter
  • Research |

    CrY2H-seq, a Cre recombinase reporter-mediated yeast two-hybrid method coupled with next-generation sequencing, enables ultra-high-throughput screening of transcription factor interactions in Arabidopsis thaliana.

    • Shelly A Trigg
    • , Renee M Garza
    • , Andrew MacWilliams
    • , Joseph R Nery
    • , Anna Bartlett
    • , Rosa Castanon
    • , Adeline Goubil
    • , Joseph Feeney
    • , Ronan O'Malley
    • , Shao-shan C Huang
    • , Zhuzhu Z Zhang
    • , Mary Galli
    •  & Joseph R Ecker

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