Biochemistry articles within Nature Chemistry

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  • Research Highlights |

    A very mild method for the selective functionalization of tyrosine residues in proteins provides an attractive new option for bioconjugation.

    • Stephen Davey

  • Article |

    Ready access to sugars in which the various hydroxyl groups are differentially protected will be of benefit in the production of vaccines, antibiotics and drugs. Here, a chemoenzymatic method that provides a direct route to such protected sugars is described.

    • Dennis G. Gillingham
    • , Pierre Stallforth
    •  & Donald Hilvert

  • Article |

    The incorporation of non-natural base pairs into double-stranded DNA, especially those mediated by metal–ligand interactions, offers new opportunities for synthetic DNA materials. The structural implications of such modifications will help guide developments in this area, and a solution structure of a B-type DNA duplex containing consecutive metal-mediated base pairs has now been elucidated.

    • Silke Johannsen
    • , Nicole Megger
    •  & Jens Müller

  • Research Highlights |

    Specific molecules in the brain can be imaged and used to make a three-dimensional model of the organ.

    • Neil Withers

  • Research Highlights |

    A synthetic functional model of the oxygen reduction site in the enzyme cytochrome c oxidase has been used to investigate the effects of hydrogen sulfide on respiration.

    • Stephen Davey

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