Lipidomics articles within Nature Chemistry

Featured

• Article | 16 February 2024

  Diazobutanone-assisted isobaric labelling of phospholipids and sulfated glycolipids enables multiplexed quantitative lipidomics using tandem mass spectrometry

  Lipidomics aims to uncover lipid functions in biological systems and disease. Quantifying lipids is challenging due to highly diverse chemical structures. Here a diazobutanone-assisted isobaric labelling method is developed that relies on diazobutanone and isobaric mass tags to target phosphate- and sulfate-containing lipids, enabling multiplexed lipidomic quantification in complex mixtures.

  • Ting-Jia Gu
  • , Peng-Kai Liu
  •  & Lingjun Li

• Article | 08 January 2018

  Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ

  Most steps in peptidoglycan biosynthesis are understood, but the lipid II binding properties to the flippases MurJ and FtsW remain unknown. Now, it has been shown that lipid II exhibits preferential binding to MurJ, which is modulated by ramoplanin and cardiolipins. These insights into the lipid II binding determinants suggest roles for lipids in regulating substrate binding.

  • Jani Reddy Bolla
  • , Joshua B. Sauer
  •  & Carol V. Robinson