Biochemistry

Definition

Biochemistry is the study of the structure and function of biological molecules such as proteins, nucleic acids, carbohydrates and lipids. Biochemistry is also used to describe techniques suited to understanding the interactions and functions of biological molecules, including traditional techniques such as Western blotting, co-immunoprecipitation, and chromatography methods.

Latest Research and Reviews

  • Reviews |

    This Review Article examines how microorganisms that have key roles in the ocean carbon and nitrogen cycles may respond to anthropogenic changes in the Earth's marine ecosystems.

    • David A. Hutchins
    •  & Feixue Fu
  • Research | | open

    Lanthanide elements are difficult to separate from aqueous solution with low energy input. Here, the authors design a peptide that recognizes and drives the precipitation of an insoluble lanthanide complex under physiological conditions, introducing a biomineralization-based approach for rare earth recovery.

    • Takaaki Hatanaka
    • , Akimasa Matsugami
    • , Takamasa Nonaka
    • , Hideki Takagi
    • , Fumiaki Hayashi
    • , Takao Tani
    •  & Nobuhiro Ishida
  • Research |

    The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.

    • Alejandra Mendoza
    • , Victoria Fang
    • , Cynthia Chen
    • , Madhavika Serasinghe
    • , Akanksha Verma
    • , James Muller
    • , V. Sai Chaluvadi
    • , Michael L. Dustin
    • , Timothy Hla
    • , Olivier Elemento
    • , Jerry E. Chipuk
    •  & Susan R. Schwab
  • Research | | open

    MxA (myxovirus resistance protein A) is a viral restriction factor whose activity depends on self-assembly into polymeric rings and helical filaments. Here the authors reveal the conformational movements involved in generating torque within polymeric MxA molecules and the dynamic conformational changes that occur upon GTP loading and hydrolysis.

    • Yang Chen
    • , Lei Zhang
    • , Laura Graf
    • , Bing Yu
    • , Yue Liu
    • , Georg Kochs
    • , Yongfang Zhao
    •  & Song Gao
  • Research | | open

    Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models.

    • Hasini Jayatilaka
    • , Pranay Tyle
    • , Jonathan J. Chen
    • , Minsuk Kwak
    • , Julia Ju
    • , Hyun Ji Kim
    • , Jerry S. H. Lee
    • , Pei-Hsun Wu
    • , Daniele M. Gilkes
    • , Rong Fan
    •  & Denis Wirtz
  • Research |

    Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

    • Anna B. Loveland
    • , Gabriel Demo
    • , Nikolaus Grigorieff
    •  & Andrei A. Korostelev

News and Comment