Featured: The Movember Collection

In partnership with the Movember Foundation, this Collection covers themes from the Global Action Plan (GAP) consortia, a worldwide collaboration between researchers in prostate and testicular cancer.

Latest Reviews

  • Review |

    WNT signalling pathway components are potentially important in prostate tumours, particularly in the development of castration-resistant prostate cancer and in the prostate tumour microenvironment. Here, Murillo-Garzón and Kypta describe our current understanding of WNT signalling in prostate cancer and discuss the potential of drugs that target this pathway.

    • Virginia Murillo-Garzón
    •  & Robert Kypta
  • Review |

    The clinical relevance of variant histology in urinary bladder cancer has been increasing, resulting in new classifications of urothelial cancers by the WHO in 2016 and highlighting the importance of an accurate morphological description of pathological specimens for the therapeutic management of patients with bladder cancer.

    • Marco Moschini
    • , David D'Andrea
    • , Stephan Korn
    • , Yasin Irmak
    • , Francesco Soria
    • , Eva Compérat
    •  & Shahrokh F. Shariat
  • Review |

    Owing to the limited operating space available, robot-assisted approaches have been rapidly adopted for procedures involving the retroperitoneal space. In this Review the authors describe the outcomes of patients undergoing robot-assisted procedures, including partial nephrectomy, radical nephrectomy, retroperitoneal lymph node dissection, nephroureterectomy and adrenalectomy, in addition to the potential of novel techniques.

    • Wesley W. Ludwig
    • , Michael A. Gorin
    • , Phillip M. Pierorazio
    •  & Mohamad E. Allaf
  • Review |

    Prostate cancer biology seems to be distinct among men of different ethnicities and races, as demonstrated by remarkable differences in the frequency of ERG oncogenic activation. In this Review, Sedarsky and colleagues discuss worldwide ERG alteration frequencies and consider how the data can be affected by variations in assay platforms and specimen types, as well as ethnic and geographical classifications, in order to realize the potential of precision medicine for men with prostate cancer.

    • Jason Sedarsky
    • , Michael Degon
    • , Shiv Srivastava
    •  & Albert Dobi
  • Review |

    High-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands suspicious for carcinoma are two prostate cancer diagnoses without standardized follow up and treatment pathways. In this Review, Tosoian and colleagues describe data that have shed light on these phenomena. The improved understanding of the implications of the presence of HGPIN and atypical glands on prostate biopsy means that clinical recommendations can be made for the management of patients with these diagnoses.

    • Jeffrey J. Tosoian
    • , Ridwan Alam
    • , Mark W. Ball
    • , H. Ballentine Carter
    •  & Jonathan I. Epstein

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