Carl Conway

Targeting B cell receptor signalling in cancer: preclinical and clinical advances

Jan A. Burger & Adrian Wiestner

Latest Reviews

  • Opinion |

    In this Opinion article, Donnem et al. outline the evidence for non-angiogenic tumours, which use pre-existing blood vessels to support tumour growth, and discuss the studies that are beginning to define their unique biology.

    • Tom Donnem
    • , Andrew R. Reynolds
    • , Elizabeth A. Kuczynski
    • , Kevin Gatter
    • , Peter B. Vermeulen
    • , Robert S. Kerbel
    • , Adrian L. Harris
    •  & Francesco Pezzella
  • Review |

    Head and neck cancer is an unexpectedly heterogeneous disease. In this Review, Leemans, Snijders and Brakenhoff provide an update on the molecular biology of head and neck cancer, outline the role of human papillomavirus and discuss the functional role of genes involved in malignant progression to identify subgroups to personalize treatment.

    • C. René Leemans
    • , Peter J. F. Snijders
    •  & Ruud H. Brakenhoff
  • Review |

    To efficiently prevent cancers associated with human papillomavirus (HPV) infection, especially cervical cancer, effective vaccines and high vaccination coverage are required. This Review provides insight into virological, immunological and strategical progress in HPV vaccines as well as implementation and potential advances.

    • Richard B. S. Roden
    •  & Peter L. Stern
  • Review |

    Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment for many haematopoietic malignancies but often results in life-threatening complications, such as graft-versus-host disease, relapse and infections. This Review discusses the potential role of intestinal microbiota in complications after allo-HSCT.

    • Yusuke Shono
    •  & Marcel R. M. van den Brink
  • Opinion |

    The abscopal effect, which is the regression of metastatic cancer at distant sites during radiotherapy, is somewhat rare but can be promoted by immunotherapy. This Opinion article describes emerging concepts and limitations of using a combination of radiotherapy and immunotherapy to boost the abscopal effect.

    • Wilfred Ngwa
    • , Omoruyi Credit Irabor
    • , Jonathan D. Schoenfeld
    • , Jürgen Hesser
    • , Sandra Demaria
    •  & Silvia C. Formenti

News & Comment

  • Research Highlight |

    Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients.

    • Ulrike Harjes
  • Research Highlight |

    Xie et al. show that senescence-associated DNA methylation changes evolve independently of stochastic tumour-associated methylation changes and that a subset of commonly methylated genes with the highest gains are associated with early tumorigenesis and ageing.

    • Anna Dart
  • Research Highlight |

    A recent study published in Nature Cell Biology has shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis.

    • Sarah Seton-Rogers
  • Research Highlight |

    Li et al. report the development of 'DNA nanorobots' carrying a thrombin protease payload that induce coagulation and necrosis at the tumour site, illustrating their therapeutic potential as drug delivery systems.

    • Conor A. Bradley
  • Research Highlight |

    Data presented by Bakhoum, Ngo et al. suggest that chromosomal instability can promote metastasis through a cGAS–STING-dependent response to cytosolic DNA.

    • Sarah Seton-Rogers

Natureevents Directory