Small molecule protein-protein interaction inhibitors in CNS therapeutics
Protein-protein interactions (PPIs) are essential for cellular function making them a fruitful source for drug targets. The central nervous system, in particular, is ripe for targeting PPIs as the highly organized nature of its signal transduction relies heavily on localization and compartmentalization of signaling functions. Read the review and learn more about recent work on small molecule inhibitors of PPIs that have the potential to affect neural functioning.

Target identification by transcriptional profiling
Gene expression changes in neuropsychiatric and neurodegenerative disorders, and gene responses to therapeutic drugs, provide new ways to identify central nervous system targets for drug discovery. In this review, Altar et al. summarize gene and pathway targets replicated in expression profiling of human postmortem brain, animal models, and cell culture studies.