The fate of T cells differentiating into the CD4 or CD8 lineage is typically fixed when cells leave the thymus. However, CD4+ helper T cells can be reprogrammed to develop into CD4+CD8α+ cytotoxic T lymphocytes in the gut.
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Anderson, M. Changing course by lymphocyte lineage redirection. Nat Immunol 14, 199–201 (2013). https://doi.org/10.1038/ni.2544
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DOI: https://doi.org/10.1038/ni.2544
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The mucosal immune system in the oral cavity—an orchestra of T cell diversity
International Journal of Oral Science (2014)