Gene regulation in immune cells

Definition

Gene regulation in immune cells refers to the mechanisms used by immune cells to increase or decrease the production of specific gene products.

Featured

Latest Research and Reviews

  • Research | | open

    The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.

    • Runqiu Jiang
    • , Junwei Tang
    • , Yun Chen
    • , Lei Deng
    • , Jie Ji
    • , Yu Xie
    • , Ke Wang
    • , Wei Jia
    • , Wen-Ming Chu
    •  & Beicheng Sun
  • Research | | open

    Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.

    • Lam C. Tsoi
    • , Philip E. Stuart
    • , Chao Tian
    • , Johann E. Gudjonsson
    • , Sayantan Das
    • , Matthew Zawistowski
    • , Eva Ellinghaus
    • , Jonathan N. Barker
    • , Vinod Chandran
    • , Nick Dand
    • , Kristina Callis Duffin
    • , Charlotta Enerbäck
    • , Tõnu Esko
    • , Andre Franke
    • , Dafna D. Gladman
    • , Per Hoffmann
    • , Külli Kingo
    • , Sulev Kõks
    • , Gerald G. Krueger
    • , Henry W. Lim
    • , Andres Metspalu
    • , Ulrich Mrowietz
    • , Sören Mucha
    • , Proton Rahman
    • , Andre Reis
    • , Trilokraj Tejasvi
    • , Richard Trembath
    • , John J. Voorhees
    • , Stephan Weidinger
    • , Michael Weichenthal
    • , Xiaoquan Wen
    • , Nicholas Eriksson
    • , Hyun M. Kang
    • , David A. Hinds
    • , Rajan P. Nair
    • , Gonçalo R. Abecasis
    •  & James T Elder
  • Research |

    BACH2 is required for lymphocyte differentiation. Afzali et al. describe mutations that cause BACH2 disruption, immunodeficiency and autoinflammatory disease via haploinsufficiency, a mechanism shared by other super-enhancer-regulated genes.

    • Behdad Afzali
    • , Juha Grönholm
    • , Jana Vandrovcova
    • , Charlotte O'Brien
    • , Hong-Wei Sun
    • , Ine Vanderleyden
    • , Fred P Davis
    • , Ahmad Khoder
    • , Yu Zhang
    • , Ahmed N Hegazy
    • , Alejandro V Villarino
    • , Ira W Palmer
    • , Joshua Kaufman
    • , Norman R Watts
    • , Majid Kazemian
    • , Olena Kamenyeva
    • , Julia Keith
    • , Anwar Sayed
    • , Dalia Kasperaviciute
    • , Michael Mueller
    • , Jason D Hughes
    • , Ivan J Fuss
    • , Mohammed F Sadiyah
    • , Kim Montgomery-Recht
    • , Joshua McElwee
    • , Nicholas P Restifo
    • , Warren Strober
    • , Michelle A Linterman
    • , Paul T Wingfield
    • , Holm H Uhlig
    • , Rahul Roychoudhuri
    • , Timothy J Aitman
    • , Peter Kelleher
    • , Michael J Lenardo
    • , John J O'Shea
    • , Nichola Cooper
    •  & Arian D J Laurence
  • Research | | open

    IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 for Il9 promoter binding and skewing these cells towards a Th1 phenotype, an effect that reduces asthmatic inflammation in mice.

    • Lucia Campos Carrascosa
    • , Matthias Klein
    • , Yohko Kitagawa
    • , Christina Lückel
    • , Federico Marini
    • , Anika König
    • , Anna Guralnik
    • , Hartmann Raifer
    • , Stefanie Hagner-Benes
    • , Diana Rädler
    • , Andreas Böck
    • , Cholho Kang
    • , Michael Lohoff
    • , Holger Garn
    • , Bianca Schaub
    • , Friederike Berberich-Siebelt
    • , Shimon Sakaguchi
    • , Tobias Bopp
    •  & Magdalena Huber
  • Research | | open

    Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific. This study finds a novel association between an immunoglobulin heavy chain allele and risk of RHD in Pacific Islanders and South Asians.

    • Tom Parks
    • , Mariana M. Mirabel
    • , Joseph Kado
    • , Kathryn Auckland
    • , Jaroslaw Nowak
    • , Anna Rautanen
    • , Alexander J. Mentzer
    • , Eloi Marijon
    • , Xavier Jouven
    • , Mai Ling Perman
    • , Tuliana Cua
    • , John K. Kauwe
    • , John B. Allen
    • , Henry Taylor
    • , Kathryn J. Robson
    • , Charlotte M. Deane
    • , Andrew C. Steer
    • , Adrian V. S. Hill
    • , Pacific Islands Rheumatic Heart Disease Genetics Network
    • , Lori Allen
    • , Marvin Allen
    • , Corinne Braunstein
    • , Samantha M. Colquhoun
    • , Aurélia Jewine
    • , Maureen Ah Kee
    • , Rina Kumar
    • , William John Martin
    • , Reapi Mataika
    • , Marie Nadra
    • , Shahin Nadu
    • , Take Naseri
    • , Baptiste Noël
    • , Nathalie Simon
    •  & Brenton Ward

News and Comment

  • News and Views |

    Increased expression of the ubiquitin ligase TRAF6 in hematopoietic stem cells promotes activity of the GTP-binding protein Cdc42 and consequent diminished function of hematopoietic stem cells by ubiquitination of the RNA-binding protein hnRNP-A1, which leads to an inability to properly process pre-mRNA encoding Cdc42-inhibitory GTPase-activating proteins.

    • Martin Turner
    •  & Elisa Monzón-Casanova
    Nature Immunology 18, 146–148
  • News and Views |

    Regulatory T cells develop in the thymus as a distinct lineage of T cells instructed by the lineage-specifying transcription factor Foxp3. Epigenetic imprinting by the genome organizer Satb1 precedes this cell-fate 'decision' during thymocyte development.

    • Marc Beyer
    •  & Jochen Huehn
    Nature Immunology 18, 144–146
  • News and Views |

    The identification of VGLL3 as a transcription (co-)factor that underlies the sex bias of the human immune system further underscores the relevance of research into this area.

    • Aridaman Pandit
    • , Linde Meyaard
    •  & Timothy R D J Radstake
    Nature Immunology 18, 142–143