Gene regulation in immune cells

Definition

Gene regulation in immune cells refers to the mechanisms used by immune cells to increase or decrease the production of specific gene products.

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Latest Research and Reviews

News and Comment

  • News and Views |

    A two-amino-acid substitution in the transcription factor RORγt disrupts its effect in establishing the transcriptional program of TH17 cells while leaving its function in the development of thymocytes and lymphoid-tissue–inducer cells largely intact.

    • Thomas Korn
    Nature Immunology 18, 1059–1060
  • News and Views |

    The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.

    • Dong-Mei Zhao
    •  & Hai-Hui Xue
    Nature Immunology 18, 957–958
  • News and Views |

    Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

    • Catherine M Biggs
    • , Henry Y Lu
    •  & Stuart E Turvey
    Nature Genetics 49, 1162–1163
  • News and Views |

    The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells, members of the Hippo family modulate autoimmune inflammation by altering interactions between the transcription factors Foxp3 and RORγt; this reveals an unexpected non-canonical role for Hippo in adaptive immunity.

    • Mandy J McGeachy
    Nature Immunology 18, 709–711