Gene regulation in immune cells


Gene regulation in immune cells refers to the mechanisms used by immune cells to increase or decrease the production of specific gene products.


Latest Research and Reviews

News and Comment

  • News and Views |

    A two-amino-acid substitution in the transcription factor RORγt disrupts its effect in establishing the transcriptional program of TH17 cells while leaving its function in the development of thymocytes and lymphoid-tissue–inducer cells largely intact.

    • Thomas Korn
    Nature Immunology 18, 1059–1060
  • News and Views |

    The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.

    • Dong-Mei Zhao
    •  & Hai-Hui Xue
    Nature Immunology 18, 957–958
  • News and Views |

    Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

    • Catherine M Biggs
    • , Henry Y Lu
    •  & Stuart E Turvey
    Nature Genetics 49, 1162–1163
  • News and Views |

    The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells, members of the Hippo family modulate autoimmune inflammation by altering interactions between the transcription factors Foxp3 and RORγt; this reveals an unexpected non-canonical role for Hippo in adaptive immunity.

    • Mandy J McGeachy
    Nature Immunology 18, 709–711