Mucosal immunology

Definition

Mucosal immunology is the study of immune responses that occur at mucosal surfaces, such as the intestines, the urogenital tract and the lungs. These tissues are closely associated with the external environment and the mucosal immune system must provide protective immunity to pathogens but remain tolerant of non-harmful environmental substances.

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Latest Research and Reviews

  • Research | | open

    Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease or ulcerative colitis, identifying that expression correlates with disease risk.

    • Nassima Fodil
    • , Neda Moradin
    • , Vicki Leung
    • , Jean-Frederic Olivier
    • , Irena Radovanovic
    • , Thiviya Jeyakumar
    • , Manuel Flores Molina
    • , Ashley McFarquhar
    • , Romain Cayrol
    • , Dominique Bozec
    • , Naglaa H. Shoukry
    • , Michiaki Kubo
    • , Julia Dimitrieva
    • , Edouard Louis
    • , Emilie Theatre
    • , Stephanie Dahan
    • , Yukihide Momozawa
    • , Michel Georges
    • , Garabet Yeretssian
    •  & Philippe Gros
  • Research |

    Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying β-cells.

    • Ophélie Rouxel
    • , Jennifer Da silva
    • , Lucie Beaudoin
    • , Isabelle Nel
    • , Céline Tard
    • , Lucie Cagninacci
    • , Badr Kiaf
    • , Masaya Oshima
    • , Marc Diedisheim
    • , Marion Salou
    • , Alexandra Corbett
    • , Jamie Rossjohn
    • , James McCluskey
    • , Raphael Scharfmann
    • , Manuela Battaglia
    • , Michel Polak
    • , Olivier Lantz
    • , Jacques Beltrand
    •  & Agnès Lehuen
  • Reviews |

    γδ T cells are found mainly in epithelial tissues, where they have crucial roles in tissue homeostasis and repair. Here, the authors describe how γδ T cells are activated and regulated in epithelial tissues, such as the skin and intestine, to mediate host microbial tolerance and provide protection against infection.

    • Morten M. Nielsen
    • , Deborah A. Witherden
    •  & Wendy L. Havran
  • Research | | open

    Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells

    • C. C. Bain
    • , J. Montgomery
    • , C. L. Scott
    • , J. M. Kel
    • , M. J. H. Girard-Madoux
    • , L. Martens
    • , T. F. P. Zangerle-Murray
    • , J. Ober-Blöbaum
    • , D. Lindenbergh-Kortleve
    • , J. N. Samsom
    • , S. Henri
    • , T. Lawrence
    • , Y. Saeys
    • , B. Malissen
    • , M. Dalod
    • , B. E. Clausen
    •  & A. McI. Mowat

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