CD4-positive T cells

Definition

CD4-positive T cells are a subtype of lymphocyte. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the restraint of most immunological functions. A key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T cell.

Latest Research and Reviews

  • Research | | open

    Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.

    • Woelsung Yi
    • , Sanjay Gupta
    • , Edd Ricker
    • , Michela Manni
    • , Rolf Jessberger
    • , Yurii Chinenov
    • , Henrik Molina
    •  & Alessandra B. Pernis
  • Research |

    Specialized populations of regulatory T cells inhabit tissues and maintain homeostasis, and assist with repair functions there. Feuerer and colleagues identify a genome-wide DNA-methylation landscape to define this specialized subset of cells.

    • Michael Delacher
    • , Charles D Imbusch
    • , Dieter Weichenhan
    • , Achim Breiling
    • , Agnes Hotz-Wagenblatt
    • , Ulrike Träger
    • , Ann-Cathrin Hofer
    • , Danny Kägebein
    • , Qi Wang
    • , Felix Frauhammer
    • , Jan-Philipp Mallm
    • , Katharina Bauer
    • , Carl Herrmann
    • , Philipp A Lang
    • , Benedikt Brors
    • , Christoph Plass
    •  & Markus Feuerer
  • Reviews |

    A growing body of evidence supports a key role for T helper type 17 (TH17) cells in the development of renal damage. This Review discusses the identification, regulation, and function of TH17 cells and their associated pathways in immune-mediated kidney diseases, with particular focus on the mechanisms underlying renal tissue injury.

    • Christian F. Krebs
    • , Tilman Schmidt
    • , Jan-Hendrik Riedel
    •  & Ulf Panzer
  • Reviews |

    This Review considers how forkhead box protein P3 (FOXP3) — the key transcription factor of regulatory T (Treg) cells — is regulated both at the transcriptional level and through post-translational modifications. The authors explain how FOXP3 interacts with other molecules to induce and maintain Treg cell populations, and they discuss the potential of therapeutically targeting FOXP3 in the context of human disease.

    • Ling Lu
    • , Joseph Barbi
    •  & Fan Pan
  • Research | | open

    Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepression of Etv5.

    • Sungjun Park
    • , Seungwon Lee
    • , Choong-Gu Lee
    • , Guk Yeol Park
    • , Hyebeen Hong
    • , Jeon-Soo Lee
    • , Young Min Kim
    • , Sung Bae Lee
    • , Daehee Hwang
    • , Youn Soo Choi
    • , John D. Fryer
    • , Sin-Hyeog Im
    • , Seung-Woo Lee
    •  & Yoontae Lee

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