CD4-positive T cells

Definition

CD4-positive T cells are a subtype of lymphocyte. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the restraint of most immunological functions. A key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T cell.

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Latest Research and Reviews

  • Research |

    Germinal centers generate high-affinity memory B cells. Qi and colleagues identify a precursor of memory B cells in germinal centers and demonstrate that the cytokine IL-9-derived from follicular helper T cells is important for their development into full-fledged memory cells.

    • Yifeng Wang
    • , Jingwen Shi
    • , Jiacong Yan
    • , Zhengtao Xiao
    • , Xiaoxiao Hou
    • , Peiwen Lu
    • , Shiyue Hou
    • , Tianyang Mao
    • , Wanli Liu
    • , Yuanwu Ma
    • , Lianfeng Zhang
    • , Xuerui Yang
    •  & Hai Qi
  • Research | | open

    IL-10+ Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and function of Tr1 cells.

    • Weishan Huang
    • , Sabrina Solouki
    • , Nicholas Koylass
    • , Song-Guo Zheng
    •  & Avery August
  • Research | | open

    The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.

    • Di Wu
    • , Yuechen Luo
    • , Wei Guo
    • , Qing Niu
    • , Ting Xue
    • , Fei Yang
    • , Xiaolei Sun
    • , Song Chen
    • , Yuanyuan Liu
    • , Jingru Liu
    • , Zhina Sun
    • , Chunxiao Zhao
    • , Huifang Huang
    • , Fang Liao
    • , Zhongchao Han
    • , Dongming Zhou
    • , Yongguang Yang
    • , Guogang Xu
    • , Tao Cheng
    •  & Xiaoming Feng
  • Research | | open

    The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an lncRNA lnc-Smad3 on the promoter accessibility of the mouse Smad3 locus.

    • Meng Xia
    • , Juan Liu
    • , Shuxun Liu
    • , Kun Chen
    • , Hongyu Lin
    • , Minghong Jiang
    • , Xiaoqing Xu
    • , Yiquan Xue
    • , Wei Liu
    • , Yan Gu
    • , Xiang Zhang
    • , Zhiqing Li
    • , Lin Yi
    • , Youcun Qian
    • , Chen Zhou
    • , Ru Li
    • , Xuan Zhang
    • , Zhanguo Li
    •  & Xuetao Cao
  • Research | | open

    T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Treg cell IL-4 production and metabolic alteration to preserve Treg lineage and function.

    • Awo Akosua Kesewa Layman
    • , Guoping Deng
    • , Claire E. O’Leary
    • , Samuel Tadros
    • , Rajan M. Thomas
    • , Joseph M. Dybas
    • , Emily K. Moser
    • , Andrew D. Wells
    • , Nicolai M. Doliba
    •  & Paula M. Oliver
  • Reviews |

    T helper 17 (TH17) cells have a well-known role in immune pathology, but they also have protective and homeostatic roles. A detailed understanding of their plasticity and how their opposing functions are regulated is crucial for enabling the therapeutic targeting of TH17 cells in disease settings.

    • Brigitta Stockinger
    •  & Sara Omenetti

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