T cells

Definition

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection.

Latest Research and Reviews

  • Research | | open

    Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.

    • Woelsung Yi
    • , Sanjay Gupta
    • , Edd Ricker
    • , Michela Manni
    • , Rolf Jessberger
    • , Yurii Chinenov
    • , Henrik Molina
    •  & Alessandra B. Pernis
  • Research |

    The authors assess the role of N 6-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.

    • Hua-Bing Li
    • , Jiyu Tong
    • , Shu Zhu
    • , Pedro J. Batista
    • , Erin E. Duffy
    • , Jun Zhao
    • , Will Bailis
    • , Guangchao Cao
    • , Lina Kroehling
    • , Yuanyuan Chen
    • , Geng Wang
    • , James P. Broughton
    • , Y. Grace Chen
    • , Yuval Kluger
    • , Matthew D. Simon
    • , Howard Y. Chang
    • , Zhinan Yin
    •  & Richard A. Flavell
  • Research | | open

    Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model.

    • Cara Haymaker
    • , Yi Yang
    • , Junmei Wang
    • , Qiang Zou
    • , Anupama Sahoo
    • , Andrei Alekseev
    • , Divyendu Singh
    • , Krit Ritthipichai
    • , Yared Hailemichael
    • , Oanh N. Hoang
    • , Hong Qin
    • , Kimberly S. Schluns
    • , Tiejun Wang
    • , Willem W. Overwijk
    • , Shao-Cong Sun
    • , Chantale Bernatchez
    • , Larry W. Kwak
    • , Sattva S. Neelapu
    •  & Roza Nurieva
  • Research |

    Specialized populations of regulatory T cells inhabit tissues and maintain homeostasis, and assist with repair functions there. Feuerer and colleagues identify a genome-wide DNA-methylation landscape to define this specialized subset of cells.

    • Michael Delacher
    • , Charles D Imbusch
    • , Dieter Weichenhan
    • , Achim Breiling
    • , Agnes Hotz-Wagenblatt
    • , Ulrike Träger
    • , Ann-Cathrin Hofer
    • , Danny Kägebein
    • , Qi Wang
    • , Felix Frauhammer
    • , Jan-Philipp Mallm
    • , Katharina Bauer
    • , Carl Herrmann
    • , Philipp A Lang
    • , Benedikt Brors
    • , Christoph Plass
    •  & Markus Feuerer
  • Reviews |

    A growing body of evidence supports a key role for T helper type 17 (TH17) cells in the development of renal damage. This Review discusses the identification, regulation, and function of TH17 cells and their associated pathways in immune-mediated kidney diseases, with particular focus on the mechanisms underlying renal tissue injury.

    • Christian F. Krebs
    • , Tilman Schmidt
    • , Jan-Hendrik Riedel
    •  & Ulf Panzer

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