In this study, we use a transcriptomic approach as a starting point to explore the heterogeneity of human GATA3-expressing lymphocytes across different tissues and disease contexts. We identify, characterize and functionally validate an abundant progenitor-like memory T cell population with the potential to sustain pathogenic TH2 cell inflammation.
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References
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This is a summary of: Kratchmarov, R. et al. TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases. Nat. Immunol. https://doi.org/10.1038/s41590-024-01803-2 (2024).
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Identification of a human multipotent TH2 progenitor. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-01818-9
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DOI: https://doi.org/10.1038/s41590-024-01818-9
