The intestinal immune response is tightly controlled to limit inflammation, largely by the cytokine IL-10, which prevents colitis. We report that the transcription factors c-MAF and BLIMP-1 induced IL-10 in T cells in the colon, but also acted to negatively regulate distinct cytokine pathways to restrict pathobiont-induced colitis.
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This is a summary of: Alvarez-Martinez, M. et al. Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis. Nat. Immunol. https://doi.org/10.1038/s41590-024-01814-z (2024).
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c-MAF and BLIMP-1 inhibit pathobiont-induced colitis by common and distinct immune pathways. Nat Immunol (2024). https://doi.org/10.1038/s41590-024-01823-y
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DOI: https://doi.org/10.1038/s41590-024-01823-y
