Bone-marrow haematopoietic-stem-cell niches

Anne Wilson and Andreas Trumpp

doi: 10.1038/nri1779

Nature Reviews Immunology 6, 93-106 (2006)

All cells of the immune system are derived from precursor cells in the bone marrow known as haematopoietic stem cells (HSCs). This Review describes recent advances in our understanding of the specialized bone-marrow niches that regulate HSC differentiation and self-renewal.

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Microenvironmental niches in the bone marrow required for B-cell development

Takashi Nagasawa

doi: 10.1038/nri1780

Nature Reviews Immunology 6, 107-116 (2006)

Recent studies have identified potential factors and cellular environments that foster B-cell development in the bone marrow. As discussed, knowledge of such microenvironmental niches and of B-cell precursor populations has advanced our understanding of the patiotemporal regulation of B-cell development.

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From stem cell to T cell: one route or many?

Avinash Bhandoola and Arivazhagan Sambandam

doi: 10.1038/nri1778

Nature Reviews Immunology 6, 117-126 (2006)

Although T cells are derived from haematopoietic stem cells in the bone marrow, T-cell development occurs in the thymus. This Review describes recent data indicating that several cell populations in the bone marrow are able to populate the thymus and generate T cells.

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Journey through the thymus: stromal guides for T-cell development and selection

Yousuke Takahama

doi: 10.1038/nri1781

Nature Reviews Immunology 6, 127-135 (2006)

As thymocytes travel through the thymus, they not only receive signals from stromal cells but also deliver signals to stromal cells, to generate the appropriate stromal environment. Takahama describes the factors involved in this lympho‐stromal crosstalk for thymocyte trafficking and T-cell-repertoire selection.

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Normal conditions suit HSCs

Karen Honey

doi: 10.1038/nri1797

Nature Reviews Immunology 6, 86 (2006)

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HSCs find their niche

Karen Honey

doi: 10.1038/nri1796

Nature Reviews Immunology 6, 90 (2006)

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T-Cell development: Premature expression of chemokine receptor CCR9 impairs T cell development.

Haematopoiesis: Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation.

Haematopoiesis: Antagonistic effect of CCAAT enhancer-binding protein-� and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors.

doi: 10.1038/nri1793

Nature Reviews Immunology 6, 89 (2006)

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