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Review
Nature Reviews Immunology 6, 127–135 (1 February 2006) | doi:10.1038/nri1781
Journey through the thymus: stromal guides for T-cell development and selection
Abstract
Lympho–stromal interactions in multiple microenvironments within the thymus have a crucial role in the regulation of T-cell development and selection. Recent studies have implicated that chemokines that are produced by thymic stromal cells have a pivotal role in positioning developing T cells within the thymus. In this Review, I discuss the importance of stroma-derived chemokines in guiding the traffic of developing thymocytes, with an emphasis on the processes of cortex-to-medulla migration and T-cell-repertoire selection, including central tolerance.
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