FOCUS
CELL SIGNALING
- Focus issue:
- March 2008 Volume 18, No 3
- April 2008 Volume 18, No 4
- May 2008 Volume 18, No 5
In three consecutive issues starting from the March 2008 issue, Cell Research presents a series of reviews on the recent advances in many important frontiers of signal transduction in the context of stem cell self-renewal and differentiation, cancer and other human diseases. In association with the review series, this focus features a collection of review and research articles that outline our current understanding of the field.
Articles
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis FREE
Shuomin Zhu, Hailong Wu, Fangting Wu, Daotai Nie, Shijie Sheng and Yin-Yuan Mo
Cell Res 18: 350-359; doi:10.1038/cr.2008.24
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Mark E. Kleinman, Kiyoshi Yamada, Atsunobu Takeda, Vasu Chandrasekaran, Miho Nozaki, Judit Z. Baffi, Romulo J. C. Albuquerque, Satoshi Yamasaki, Masahiro Itaya, Yuzhen Pan, Binoy Appukuttan, Daniel Gibbs, Zhenglin Yang, Katalin Karikó, Balamurali K. Ambati, Traci A. Wilgus, Luisa A. DiPietro, Eiji Sakurai, Kang Zhang, Justine R. Smith, Ethan W. Taylor & Jayakrishna Ambati
Nature 452: 591-597; doi:10.1038/nature06765
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Ilaria Malanchi, Hector Peinado, Deepika Kassen, Thomas Hussenet, Daniel Metzger, Pierre Chambon, Marcel Huber, Daniel Hohl, Amparo Cano, Walter Birchmeier & Joerg Huelsken
Nature 452: 650-653; doi:10.1038/nature06835
Translational control of the innate immune response through IRF-7
Rodney Colina, Mauro Costa-Mattioli, Ryan J. O. Dowling, Maritza Jaramillo, Lee-Hwa Tai, Caroline J. Breitbach, Yvan Martineau, Ola Larsson, Liwei Rong, Yuri V. Svitkin, Andrew P. Makrigiannis, John C. Bell & Nahum Sonenberg
Nature 452: 323-328; doi:10.1038/nature06730
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Daniel A. Muruve, Virginie Pétrilli, Anne K. Zaiss, Lindsay R. White, Sharon A. Clark, P. Joel Ross, Robin J. Parks & Jurg Tschopp
Nature 452: 103-107; doi:10.1038/nature06664
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
Xiaoyong Yang, Pat P. Ongusaha, Philip D. Miles, Joyce C. Havstad, Fengxue Zhang, W. Venus So, Jeffrey E. Kudlow, Robert H. Michell, Jerrold M. Olefsky, Seth J. Field & Ronald M. Evans
Nature 451: 964-969; doi:10.1038/nature06668
Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
Sang-Dong Yoo, Young-Hee Cho, Guillaume Tena, Yan Xiong & Jen Sheen
Nature 451: 789-795; doi:10.1038/nature06543
NUMB controls p53 tumour suppressor activity
Ivan N. Colaluca, Daniela Tosoni, Paolo Nuciforo, Francesca Senic-Matuglia, Viviana Galimberti, Giuseppe Viale, Salvatore Pece & Pier Paolo Di Fiore
Nature 451: 76-80; doi:10.1038/nature06412
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
Maksim V. Plikus, Julie Ann Mayer, Damon de la Cruz, Ruth E. Baker, Philip K. Maini, Robert Maxson & Cheng-Ming Chuong
Nature 451: 340-344; doi:10.1038/nature06457
MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth FREE
Julia Schultz, Peter Lorenz, Gerd Gross, Saleh Ibrahim and Manfred Kunz
Cell Res 18: 549-557; doi:10.1038/cr.2008.45
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