Making progress with limb models. Denis Duboule, Nature 1 August (2002)News and Views article, which describes new work that challenges the 'progress zone' model of limb development. It proposes instead that all of the various cell types to form a limb are specified at the same time, early in development, and that they expand at different times afterwards to form the complete limb.

Computationally predicting eukaryotic protein coding genes Michael Q. Zhang Nature Reviews Genetics September (2002).

Beyond the role of glutamate as a neurotransmitter Maiken Nedergaard, Takahiro Takano and Anker J. Hansen Nature Reviews Neuroscience September (2002).

Chromatin modification and epigenetic reprogramming in mammalian development En Li Nature Reviews Genetics September (2002).

Protein tyrosine phosphatase 1B inhibitors Theodore O. Johnson, Jacques Ermolieff and Michael R. Jirousek Nature Reviews Drug Discovery September (2002).

Calcium callisthenics. N. Michael Green and David H. MacLennan, Nature 8 August (2002).

Unconventional ways to travel Markus Schober and Norbert Perrimon Nature Cell Biology September (2002).News and Views article that describes a new mechanism in cell migration from studies on Drosophila border cells.

The Bcl-2 family: regulators of the cellular life-or-death switch Suzanne Cory and Jerry Adams Nature Reviews Cancer September (2002).

Molecular basis of the VHL hereditary cancer syndrome William G. Kaelin, Jr Nature Reviews Cancer September (2002).

Telomeres in T and B cells Richard J. Hodes, Karen S. Hathcock and Nan-ping Weng Nature Reviews Immunology September (2002).

WASp in immune-system organization and function Adrian J. Thrasher Nature Reviews Immunology September (2002).

ATPases as drug targets: learning from their structure Patrick Chène Nature Reviews Drug Discovery September (2002).

Viruses and interferon: a fight for supremacy Michael G. Katze, Yupeng He and Michael Gale, Jr Nature Reviews Immunology September (2002). Interferons are produced by host cells in response to viruses; viruses, in turn, have mechanisms to counteract these responses. This review article discusses current understanding of the complex network of cellular antiviral processes.