●Cancer: stuck at first base.van der Weyden, L., Jonkers, J. & Bradley, A. Nature 12 September (2002) Peutz–Jeghers syndrome is a familial polyposis disease; however, the polyps rarely progress to malignancy. This News and Views article describes a mouse model that is helping to elucidate why this might be so.

●Functional significance of the perforin/granzyme cell-death pathway. Trapani J. A. & Smyth, M. J. Nature Reviews Immunology October (2002)

●Breast cancer banishes p27 from the nucleus. Blain, S. W. & Massague, J. Nature Medicine October (2002) The CDK inhibitor p27 can halt cell proliferation, but breast cancer cells have found a way of removing it from the equation. This News and Views article describes how phosphorylation of p27 results in its nuclear exclusion.

●Furin at the cutting edge: from protein traffic to embryogenesis and disease. Thomas, G. Nature Reviews Molecular Cell Biology October (2002)

●Gene silencing in mammals by siRNAs. McManus, M. T. & Sharp, P. A. Nature Reviews Genetics October (2002)

●The many functions of SMC proteins in chromosome dynamics. Jessberger, R. Nature Reviews Molecular Cell Biology October (2002)

●Structural biology of insulin and IGF-1 receptors: implications for drug design. De Meyts, P. & Whittaker, J. Nature Reviews Drug Dicovery October (2002)

●EBV framed in Burkitt lymphoma. Speck, S. H. Nature Medicine October (2002) This News and Views article describes the role of Epstein–Barr-virus-driven B-cell proliferation in the genesis of Burkitt lymphoma.

●Forty-six chromosomes and 46 years of human cytogenetics. Trask, B. J. Nature Reviews Genetics October (2002)