Adenosine-to-inosine RNA editing by ADAR adenosine deaminases can alter the gene targets of microRNAs (miRNAs). Shoshan and Mobley et al. have shown that ADAR1 expression is low in metastatic melanoma, and that restoring its expression suppresses melanoma growth and metastasis in vivo. The miRNA miR-455-5p had a different set of gene targets when edited by ADAR1. Unedited miR-455-5p inhibited the tumour suppressor CPEB1, whereas edited miR-455-5p increased CPEB1 expression and suppressed melanoma growth and metastasis.
References
Shoshan, E. & Mobley, A. K. et al. Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. Nature Cell Biol. 17, 311–321 (2015)
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Seton-Rogers, S. Editing suppresses melanoma progression. Nat Rev Cancer 15, 198 (2015). https://doi.org/10.1038/nrc3936
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DOI: https://doi.org/10.1038/nrc3936
