Melanoma

Definition

Melanoma is the most serious type of skin cancer. It develops when skin cells multiply rapidly as a consequence of mutations in their DNA caused by UV exposure. Melanomas originate in the pigment-producing melanocytes in the basal layer of the epidermis; they often resemble moles and are generally black or dark brown.

Latest Research and Reviews

  • Research | | open

    The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.

    • Coralie Dorard
    • , Charlène Estrada
    • , Céline Barbotin
    • , Magalie Larcher
    • , Alexandra Garancher
    • , Jessy Leloup
    • , Friedrich Beermann
    • , Manuela Baccarini
    • , Celio Pouponnot
    • , Lionel Larue
    • , Alain Eychène
    •  & Sabine Druillennec
  • Research |

    The first large, high-coverage whole-genome sequencing study of melanomas from cutaneous, acral and mucosal sites.

    • Nicholas K. Hayward
    • , James S. Wilmott
    • , Nicola Waddell
    • , Peter A. Johansson
    • , Matthew A. Field
    • , Katia Nones
    • , Ann-Marie Patch
    • , Hojabr Kakavand
    • , Ludmil B. Alexandrov
    • , Hazel Burke
    • , Valerie Jakrot
    • , Stephen Kazakoff
    • , Oliver Holmes
    • , Conrad Leonard
    • , Radhakrishnan Sabarinathan
    • , Loris Mularoni
    • , Scott Wood
    • , Qinying Xu
    • , Nick Waddell
    • , Varsha Tembe
    • , Gulietta M. Pupo
    • , Ricardo De Paoli-Iseppi
    • , Ricardo E. Vilain
    • , Ping Shang
    • , Loretta M. S. Lau
    • , Rebecca A. Dagg
    • , Sarah-Jane Schramm
    • , Antonia Pritchard
    • , Ken Dutton-Regester
    • , Felicity Newell
    • , Anna Fitzgerald
    • , Catherine A. Shang
    • , Sean M. Grimmond
    • , Hilda A. Pickett
    • , Jean Y. Yang
    • , Jonathan R. Stretch
    • , Andreas Behren
    • , Richard F. Kefford
    • , Peter Hersey
    • , Georgina V. Long
    • , Jonathan Cebon
    • , Mark Shackleton
    • , Andrew J. Spillane
    • , Robyn P. M. Saw
    • , Núria López-Bigas
    • , John V. Pearson
    • , John F. Thompson
    • , Richard A. Scolyer
    •  & Graham J. Mann
    Nature 545, 175–180
  • Research |

    The clinical benefit of anti-PD-1 antibody treatment is dependent on the extent to which exhausted CD8 T cells are reinvigorated in relation to the tumour burden of the patient.

    • Alexander C. Huang
    • , Michael A. Postow
    • , Robert J. Orlowski
    • , Rosemarie Mick
    • , Bertram Bengsch
    • , Sasikanth Manne
    • , Wei Xu
    • , Shannon Harmon
    • , Josephine R. Giles
    • , Brandon Wenz
    • , Matthew Adamow
    • , Deborah Kuk
    • , Katherine S. Panageas
    • , Cristina Carrera
    • , Phillip Wong
    • , Felix Quagliarello
    • , Bradley Wubbenhorst
    • , Kurt D’Andrea
    • , Kristen E. Pauken
    • , Ramin S. Herati
    • , Ryan P. Staupe
    • , Jason M. Schenkel
    • , Suzanne McGettigan
    • , Shawn Kothari
    • , Sangeeth M. George
    • , Robert H. Vonderheide
    • , Ravi K. Amaravadi
    • , Giorgos C. Karakousis
    • , Lynn M. Schuchter
    • , Xiaowei Xu
    • , Katherine L. Nathanson
    • , Jedd D. Wolchok
    • , Tara C. Gangadhar
    •  & E. John Wherry
    Nature 545, 60–65

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