Melanoma

Definition

Melanoma is the most serious type of skin cancer. It develops when skin cells multiply rapidly as a consequence of mutations in their DNA caused by UV exposure. Melanomas originate in the pigment-producing melanocytes in the basal layer of the epidermis; they often resemble moles and are generally black or dark brown.

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Latest Research and Reviews

  • Research | | open

    Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms.

    • Iwei Yeh
    • , Ursula E. Lang
    • , Emeline Durieux
    • , Meng Kian Tee
    • , Aparna Jorapur
    • , A. Hunter Shain
    • , Veronique Haddad
    • , Daniel Pissaloux
    • , Xu Chen
    • , Lorenzo Cerroni
    • , Robert L. Judson
    • , Philip E. LeBoit
    • , Timothy H. McCalmont
    • , Boris C. Bastian
    •  & Arnaud de la Fouchardière
  • Research | | open

    Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.

    • Rajasekharan Somasundaram
    • , Gao Zhang
    • , Mizuho Fukunaga-Kalabis
    • , Michela Perego
    • , Clemens Krepler
    • , Xiaowei Xu
    • , Christine Wagner
    • , Denitsa Hristova
    • , Jie Zhang
    • , Tian Tian
    • , Zhi Wei
    • , Qin Liu
    • , Kanika Garg
    • , Johannes Griss
    • , Rufus Hards
    • , Margarita Maurer
    • , Christine Hafner
    • , Marius Mayerhöfer
    • , Georgios Karanikas
    • , Ahmad Jalili
    • , Verena Bauer-Pohl
    • , Felix Weihsengruber
    • , Klemens Rappersberger
    • , Josef Koller
    • , Roland Lang
    • , Courtney Hudgens
    • , Guo Chen
    • , Michael Tetzlaff
    • , Lawrence Wu
    • , Dennie Tompers Frederick
    • , Richard A. Scolyer
    • , Georgina V. Long
    • , Manashree Damle
    • , Courtney Ellingsworth
    • , Leon Grinman
    • , Harry Choi
    • , Brian J. Gavin
    • , Margaret Dunagin
    • , Arjun Raj
    • , Nathalie Scholler
    • , Laura Gross
    • , Marilda Beqiri
    • , Keiryn Bennett
    • , Ian Watson
    • , Helmut Schaider
    • , Michael A. Davies
    • , Jennifer Wargo
    • , Brian J. Czerniecki
    • , Lynn Schuchter
    • , Dorothee Herlyn
    • , Keith Flaherty
    • , Meenhard Herlyn
    •  & Stephan N. Wagner
  • Research | | open

    The clinical management of metastatic melanoma requires predictors of the response to checkpoint blockade. Here, the authors use immunological assays to identify potential prognostic/predictive biomarkers in circulating blood cells and in tumor-infiltrating lymphocytes from patients with resected stage III melanoma.

    • N. Jacquelot
    • , M. P. Roberti
    • , D. P. Enot
    • , S. Rusakiewicz
    • , N. Ternès
    • , S. Jegou
    • , D. M. Woods
    • , A. L. Sodré
    • , M. Hansen
    • , Y. Meirow
    • , M. Sade-Feldman
    • , A. Burra
    • , S. S. Kwek
    • , C. Flament
    • , M. Messaoudene
    • , C. P. M. Duong
    • , L. Chen
    • , B. S. Kwon
    • , A. C. Anderson
    • , V. K. Kuchroo
    • , B. Weide
    • , F. Aubin
    • , C. Borg
    • , S. Dalle
    • , O. Beatrix
    • , M. Ayyoub
    • , B. Balme
    • , G. Tomasic
    • , A. M. Giacomo
    • , M. Maio
    • , D. Schadendorf
    • , I. Melero
    • , B. Dréno
    • , A. Khammari
    • , R. Dummer
    • , M. Levesque
    • , Y. Koguchi
    • , L. Fong
    • , M. Lotem
    • , M. Baniyash
    • , H. Schmidt
    • , I. M. Svane
    • , G. Kroemer
    • , A. Marabelle
    • , S. Michiels
    • , A. Cavalcanti
    • , M. J. Smyth
    • , J. S. Weber
    • , A. M. Eggermont
    •  & L. Zitvogel

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