●Clostridia in cancer therapy. Minton, N. P. Nature Reviews Microbiology December (2003) An effective means of delivering anticancer agents to tumours still remains to be discovered. Could bacterial spores be the answer? Find out by reading this Innovation article.

●Getting to the end: telomerase access in yeast and humans. Vega, L. R., Mateyak, M. K. & Zakian, V. A. Nature Reviews Molecular Cell Biology December (2003)

●RNAi collection.Nature Reviews Molecular Cell Biology, Nature Reviews Genetics and Nature Reviews Drug Discovery December (2003) The RNAi reprint supplement is a group of Highlights, Perspectives and Reviews that focus on key advances in RNAi research. The articles are part of a Web Focus on the same topic that is free for 6 months.

●A twist in a hedgehog's tale. Scott, M. P. Nature 23 October (2003) This News and Views article discusses two Nature papers in the same issue that implicate the Hedgehog signalling pathway in the genesis of cancers of the gut.

●Met, metastasis, motility and more. Birchmeier, C., Birchmeier, W., Gherardi, E. & Vande Woude, G. F. Nature Reviews Molecular Cell Biology December (2003)

●The mechanisms of immune diversification and their disorders: from immune deficiencies to lymphomas. de Villartay, J.-P., Fischer, A. & Durandy, A. Nature Reviews Immunology December (2003)

●Pharmacogenetics goes genomic. Goldstein, D. B., Tate, S. K. & Sisodiya, S. M. Nature Reviews Genetics December (2003)

●Fresh assault on hepatitis C. Rice, C. M. Nature 13 November (2003) Hepatitis C virus (HCV) causes severe liver disease and increases the risk of liver cancer by 100-fold. The success of the first human trials using small-molecule inhibitors of HCV is discussed in this News and Views article.

●Cancer vaccine targets leukemia. Donnelly, J. Nature Medicine November (2003) This News and Views describes how a cancer vaccine has been used to successfully shrink mouse tumours.