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Glimpsing the real CD4+ T cell response

Nature Immunology volume 11, pages 47–49 (2010)Cite this article

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The present views of how CD4+ T cells respond to antigen are based largely on artificial systems. A highly sensitive approach that allows normal T cell responses to be monitored in physiological conditions overturns some existing ideas about the differentiation of CD4+ T cells.

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Figure 1: Endogenous CD4+ T cell responses to intravenous and intranasal infection with L. monocytogenes.

References

  1. Kaech, S.M., Wherry, E.J. & Ahmed, R. Nat. Rev. Immunol. 2, 251–262 (2002).

    Article  CAS  Google Scholar 

  2. Pepper, M. et al. Nat. Immunol. 11, 83–89 (2010).

    Article  CAS  Google Scholar 

  3. Zhou, L., Chong, M.M. & Littman, D.R. Immunity 30, 646–655 (2009).

    Article  CAS  Google Scholar 

  4. Jenkins, M.K. et al. Annu. Rev. Immunol. 19, 23–45 (2001).

    Article  CAS  Google Scholar 

  5. Hataye, J., Moon, J.J., Khoruts, A., Reilly, C. & Jenkins, M.K. Science 312, 114–116 (2006).

    Article  CAS  Google Scholar 

  6. Moon, J.J. et al. Immunity 27, 203–213 (2007).

    Article  CAS  Google Scholar 

  7. Foulds, K.E. et al. J. Immunol. 168, 1528–1532 (2002).

    Article  CAS  Google Scholar 

  8. Purton, J.F. et al. J. Exp. Med. 204, 951–961 (2007).

    Article  CAS  Google Scholar 

  9. Homann, D., Teyton, L. & Oldstone, M.B. Nat. Med. 7, 913–919 (2001).

    Article  CAS  Google Scholar 

  10. Tokoyoda, K. et al. Immunity 30, 721–730 (2009).

    Article  CAS  Google Scholar 

  11. Hikono, H. et al. J. Exp. Med. 204, 1625–1636 (2007).

    Article  CAS  Google Scholar 

  12. Sallusto, F., Geginat, J. & Lanzavecchia, A. Annu. Rev. Immunol. 22, 745–763 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Charles D. Surh is in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA, and World Class University–Integrative Biosciences and Biotechnology Program, Pohang University of Science and Technology, Pohang, Korea.,

    Charles D Surh

  2. Jonathan Sprent is with the Garvan Institute of Medical Research, Sydney, New South Wales, Australia, and World Class University–Integrative Biosciences and Biotechnology Program, Pohang University of Science and Technology, Pohang, Korea.,

    Jonathan Sprent

Authors
  1. Charles D Surh
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  2. Jonathan Sprent
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Correspondence to Charles D Surh.

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Surh, C., Sprent, J. Glimpsing the real CD4+ T cell response. Nat Immunol 11, 47–49 (2010). https://doi.org/10.1038/ni0110-47

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