Systems biology articles within Nature Communications

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• Article | 09 August 2011

  Delay-induced anomalous fluctuations in intracellular regulation

  Direct negative feedback decreases fluctuations in homoeostatic control, but intracellular regulatory systems are indirect. Here, an analytical expression is derived to show that indirect feedback in transcription and translation leads to more fluctuations for intermediate delays but not for long delays.

  • Andreas Grönlund
  • , Per Lötstedt
  •  & Johan Elf

• Article | 21 December 2010

  Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

  The integration of microarray and metabolite data is important for understanding the physiology of model organisms. This study demonstrates how the integration of these kinds of data can provide novel insights into the growth and protein metabolism of two different yeast strains.

  • André B. Canelas
  • , Nicola Harrison
  •  & Jens Nielsen

• Article
  02 November 2010 | Open Access

  Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

  Sixty years ago it was suggested that the sickle cell disease mutation survives because the heterozygous genotype confers resistance to malaria, resulting in correlation of the two geographical distributions. The authors use a new global assembly of sickle allele frequencies to support this hypothesis at the global scale.

  • Frédéric B. Piel
  • , Anand P. Patil
  •  & Simon I. Hay