Systems biology

Definition

Systems biology is the study of biological systems whose behaviour cannot be reduced to the linear sum of their parts’ functions. Systems biology does not necessarily involve large numbers of components or vast datasets, as in genomics or connectomics, but often requires quantitative modelling methods borrowed from physics.

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Latest Research and Reviews

  • Reviews |

    The emergence of synthetic fluorescent nucleobases that can be incorporated into DNA and RNA in place of their natural counterparts has enabled new tools and technologies with applications in chemistry, biology and biomedicine. This Review discusses chemical insights into canonical and non-canonical nucleobase designs, relating structure to properties.

    • Wang Xu
    • , Ke Min Chan
    •  & Eric T. Kool
  • Research |

    The use of phage-assisted continuous evolution (PACE) with both positive and negative selection enables the rapid development of orthogonal aminoacyl-tRNA synthetases with high activity and selectivity for noncanonical amino acids.

    • David I Bryson
    • , Chenguang Fan
    • , Li-Tao Guo
    • , Corwin Miller
    • , Dieter Söll
    •  & David R Liu
  • Research |

    Protein origami using coiled-coil building blocks produces self-assembling polyhedral cages for diverse applications.

    • Ajasja Ljubetič
    • , Fabio Lapenta
    • , Helena Gradišar
    • , Igor Drobnak
    • , Jana Aupič
    • , Žiga Strmšek
    • , Duško Lainšček
    • , Iva Hafner-Bratkovič
    • , Andreja Majerle
    • , Nuša Krivec
    • , Mojca Benčina
    • , Tomaž Pisanski
    • , Tanja Ćirković Veličković
    • , Adam Round
    • , José María Carazo
    • , Roberto Melero
    •  & Roman Jerala
  • Research |

    A microfluidics method to generate giant, copolymer-stabilized liposomes is presented. These vesicles are functionalized with distinct proteins to recapitulate cellular processes.

    • Marian Weiss
    • , Johannes Patrick Frohnmayer
    • , Lucia Theresa Benk
    • , Barbara Haller
    • , Jan-Willi Janiesch
    • , Thomas Heitkamp
    • , Michael Börsch
    • , Rafael B. Lira
    • , Rumiana Dimova
    • , Reinhard Lipowsky
    • , Eberhard Bodenschatz
    • , Jean-Christophe Baret
    • , Tanja Vidakovic-Koch
    • , Kai Sundmacher
    • , Ilia Platzman
    •  & Joachim P. Spatz
  • Research |

    A reverse two-hybrid approach combined with massively parallel programmed mutagenesis and sequencing allows profiling protein interaction determinants at amino-acid resolution, as demonstrated by identifying interaction-disrupting mutations in a cilia protein complex associated with Bardet–Biedl syndrome.

    • Jonathan Woodsmith
    • , Luise Apelt
    • , Victoria Casado-Medrano
    • , Ziya Özkan
    • , Bernd Timmermann
    •  & Ulrich Stelzl

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