Systems biology

Definition

Systems biology is the study of biological systems whose behaviour cannot be reduced to the linear sum of their parts’ functions. Systems biology does not necessarily involve large numbers of components or vast datasets, as in genomics or connectomics, but often requires quantitative modelling methods borrowed from physics.

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Latest Research and Reviews

  • Research |

    Monocle 2 uses reversed graph embedding to automatically learn complex, branched pseudotime trajectories of differentiation or cellular state changes from single-cell expression data.

    Monocle 2 uses reversed graph embedding to automatically learn complex, branched pseudotime trajectories of differentiation or cellular state changes from single-cell expression data.

    • Xiaojie Qiu
    • , Qi Mao
    • , Ying Tang
    • , Li Wang
    • , Raghav Chawla
    • , Hannah A Pliner
    •  & Cole Trapnell
  • Research |

    The first demonstration of a protein designed entirely from first principles that binds a small-molecule cofactor in a precisely predetermined orientation has now been described. The design method utilizes a remote protein core that both anchors and predisposes a flexible binding site for the desired cofactor-binding geometry.

    • Nicholas F. Polizzi
    • , Yibing Wu
    • , Thomas Lemmin
    • , Alison M. Maxwell
    • , Shao-Qing Zhang
    • , Jeff Rawson
    • , David N. Beratan
    • , Michael J. Therien
    •  & William F. DeGrado
  • Research |

    FreemoVR is a virtual reality system for freely moving animals. The versatile platform is demonstrated in various experiments with Drosophila, zebrafish, and mice.

    • John R Stowers
    • , Maximilian Hofbauer
    • , Renaud Bastien
    • , Johannes Griessner
    • , Peter Higgins
    • , Sarfarazhussain Farooqui
    • , Ruth M Fischer
    • , Karin Nowikovsky
    • , Wulf Haubensak
    • , Iain D Couzin
    • , Kristin Tessmar-Raible
    •  & Andrew D Straw

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