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| Open AccessHysteresis of tropical forests in the 21st century
Tropical rainforests partly create their own climatic conditions by promoting precipitation, therefore rainforest losses may trigger dramatic shifts. Here the authors combine remote sensing, hydrological modelling, and atmospheric moisture tracking simulations to assess forest-rainfall feedbacks in three major tropical rainforest regions on Earth and simulate potential changes under a severe climate change scenario.
- Arie Staal
- , Ingo Fetzer
- & Obbe A. Tuinenburg
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Article
| Open AccessMultistable and dynamic CRISPRi-based synthetic circuits
Synthetic circuits based on CRISPRi have not achieved multistable and dynamic behaviors. Here the authors build an oscillator, a toggle switch and an incoherent feed-forward loop using CRISPRi, and provide a mathematical model suggesting that unspecific binding in CRISPRi enables multistability.
- Javier Santos-Moreno
- , Eve Tasiudi
- & Yolanda Schaerli
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Article
| Open AccessA mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
Dysregulation of insulin secretion dynamics plays a role in diabetes development. Here, the authors build a mathematical model of hepatic insulin signaling and propose a sequential model of post-meal control of glucose and lipids, according to which delayed aPKC suppression would contribute to selective hepatic insulin resistance.
- Gang Zhao
- , Dagmar Wirth
- & Michael Meyer-Hermann
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Article
| Open AccessBoosting functionality of synthetic DNA circuits with tailored deactivation
Nonlinearity in synthetic molecular circuits is usually achieved by manipulation of network topology or of production kinetics. Here, the authors achieve bistability and other nonlinear behaviours by manipulating the individual degradation rate laws of circuit components using saturable pathways.
- Kevin Montagne
- , Guillaume Gines
- & Yannick Rondelez