Stem cells articles within Nature

Featured

  • News & Views |

    In the earliest stages of mammalian development, individual cells possess the unrestricted potential to form a new organism. Researchers are closing in on the goal of growing these cells in the laboratory.

    • Martin F. Pera

  • Article |

    Glioblastoma stem cells co-opt lysine uptake and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to evade interferon-induced intrinsic effects on glioblastoma stem cell maintenance and extrinsic effects on immune response.

    • Huairui Yuan
    • , Xujia Wu
    •  & Jeremy N. Rich

  • News & Views |

    The observation that melanocyte stem cells migrate up and down the hair follicle, differentiating into melanocytes and then returning to a stem-cell identity, calls into question long-held assumptions about adult stem cells.

    • Carlos Galvan
    •  & William E. Lowry

  • Article
    | Open Access

    Local microenvironmental cues modulate melanocyte stem cells, which control hair pigmentation, to enter different differentiation states, shifting between hair follicle stem cell and transit-amplifying compartments, a process that is different to other self-renewing systems.

    • Qi Sun
    • , Wendy Lee
    •  & Mayumi Ito

  • Article |

    Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • , Jayakrishnan Gopakumar
    •  & Siddhartha Jaiswal

  • News & Views |

    A screen of mouse stem cells that exploits their propensity to gain or lose chromosomes in cell culture has been used to convert male XY to female XX cells. Subsequent differentiation generates functional eggs and live offspring.

    • Jonathan Bayerl
    •  & Diana J. Laird

  • Article |

    Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring after fertilization.

    • Kenta Murakami
    • , Nobuhiko Hamazaki
    •  & Katsuhiko Hayashi

  • Article |

    Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.

    • Andrew G. Soerens
    • , Marco Künzli
    •  & David Masopust

  • Research Briefing |

    More than 200,000 human stem cells were imaged at high resolution and in 3D to make a reference data set that was used to create a generalizable computational framework. This enables cell shapes and the locations of internal structures to be measured and compared using rigorous statistical methods.

  • News & Views |

    Cells in a state of arrested growth, called senescence, have been characterized in skeletal muscle in mice. Senescent cells promote inflammation and block regeneration, and thus might induce harmful changes in aged muscle.

    • David J. Glass

  • Article |

    Somitoids and segmentoids—culture systems that recapitulate the formation of somite-like structures—reveal that an initial salt-and-pepper expression pattern of MESP2 in a newly formed segment is transformed into compartments of anterior and posterior identity through an active cell-sorting mechanism.

    • Yuchuan Miao
    • , Yannis Djeffal
    •  & Olivier Pourquié

  • Article
    | Open Access

    A lifetime cartography of in vivo senescent cells shows that they are heterogeneous. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing and arrests stem cell proliferation and tissue regeneration.

    • Victoria Moiseeva
    • , Andrés Cisneros
    •  & Pura Muñoz-Cánoves

  • Article |

    A 3D model of human segmentation and somitogenesis derived from induced pluripotent stem cells captures the oscillatory dynamics of the segmentation clock as well as morphological and molecular features of the developing embryonic axis and tail.

    • Yoshihiro Yamanaka
    • , Sofiane Hamidi
    •  & Cantas Alev

  • Research Briefing |

    Supplies of the crucial molecules ATP and NADPH are lacking in many human diseases, but restoring them requires tight control. Using light-powered thylakoid structures from plants to carefully deliver these molecules to the joints of arthritic mice slowed degeneration.

  • News & Views |

    Improved treatments for spinal-cord injury require both technological development and insights into the biology of recovery. High-resolution molecular maps of the nervous system are beginning to provide the latter.

    • Kee Wui Huang
    •  & Eiman Azim

  • Article
    | Open Access

    A multi-omic atlas of brain organoid development facilitates the inference of an underlying gene regulatory network using the newly developed Pando framework and shows—in conjunction with perturbation experiments—that GLI3 controls forebrain fate establishment through interaction with HES4/5 regulomes.

    • Jonas Simon Fleck
    • , Sophie Martina Johanna Jansen
    •  & Barbara Treutlein

  • News & Views |

    Two groups have grown self-organizing models of mouse embryos from stem cells in vitro. The models mimic mid-gestation embryos, providing an unparalleled opportunity to study early embryonic development.

    • Neal D. Amin
    •  & Sergiu P. Pașca

  • Article
    | Open Access

    Synthetic mouse embryos assembled from embryonic stem cells, trophoblast stem cells and induced extraembryonic endoderm stem cells closely recapitulate the development of wild-type and mutant natural mouse embryos up to embryonic day 8.5.

    • Gianluca Amadei
    • , Charlotte E. Handford
    •  & Magdalena Zernicka-Goetz

  • News & Views |

    A dynamic mode of stem-cell regulation has been discovered. Intestinal stem cells use migration to maintain a large pool of multifunctional cells, perhaps endowing the organ with robust responses to injury.

    • Stephanie J. Ellis
    •  & Elaine Fuchs

  • Article |

    Small intestinal crypts contain twice as many effective stem cells as large intestinal crypts, and this difference is determined by the degree of Wnt-driven retrograde cell movement—which is largely absent in the large intestine—counteracting conveyor-belt-like upward movement.

    • Maria Azkanaz
    • , Bernat Corominas-Murtra
    •  & Jacco van Rheenen

  • Article |

    3D transcriptomes reveal the molecular code of lineage specification in the primate embryo and provide an in vivo reference to decipher human development.

    • Sophie Bergmann
    • , Christopher A. Penfold
    •  & Thorsten E. Boroviak

  • Article |

    In situ barcoding and fate mapping in mice reveals that an early wave of progenitor specification, driven by embryonic multipotent progenitor cells, gives rise to adult blood independently of haematopoietic stem cells.

    • Sachin H. Patel
    • , Constantina Christodoulou
    •  & Fernando D. Camargo

  • News & Views |

    Two studies of the mutations acquired by blood-forming cells over time provide insights into the dynamics of blood production in humans and its relationship to ageing.

    • Aswin Sekar
    •  & Benjamin L. Ebert

  • Article
    | Open Access

    Haematopoiesis has high clonal diversity up to about 65 years of age, after which diversity drops precipitously owing to positive selection acting on a handful of clones that expand exponentially throughout adulthood.

    • Emily Mitchell
    • , Michael Spencer Chapman
    •  & Peter J. Campbell

  • News & Views |

    Neuronal fibres have been tracked as they regrow into the skin following nerve injury in mice. The analysis reveals that mis-wiring of pain-sensing fibres generates hypersensitivity to touch in skin associated with the injury.

    • Suna L. Cranfill
    •  & Wenqin Luo

  • Article |

    Characterization of Gibbin, encoded by AHDC1, offers insights into the epidermal and mesodermal patterning phenotypes seen in Xia–Gibbs and related syndromes in humans, which derive from abnormal mesoderm maturation as a result of gene-specific DNA methylation decisions.

    • Ann Collier
    • , Angela Liu
    •  & Anthony E. Oro

  • Article |

    Organoids originating from human multipotent ocular surface epithelial stem cells are similar to native lacrimal glands and undergo functional maturation when transplanted adjacent to the eyes of recipient rats, developing lumina and producing tear-film proteins.

    • Ryuhei Hayashi
    • , Toru Okubo
    •  & Kohji Nishida

  • Article |

    Spatial transcriptomics and single-cell profiling identify previously uncharacterized cell types of human terminal and respiratory bronchioles, and show that cell differentiation and lineage trajectories are distinct from those in the mouse lung.

    • Preetish Kadur Lakshminarasimha Murthy
    • , Vishwaraj Sontake
    •  & Purushothama Rao Tata

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