Muscle stem cells articles within Nature

Featured

• Article | 10 February 2021

  Macrophages provide a transient muscle stem cell niche via NAMPT secretion

  Specific macrophage populations provide a transient niche that activates muscle stem cells after muscle injury and supply proliferation-inducing cues that govern the repair process mediated by these cells in both zebrafish and mouse injury models.

  • Dhanushika Ratnayake
  • , Phong D. Nguyen
  •  & Peter D. Currie

• Letter | 23 May 2018

  Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

  Muscle stem cell quiescence in mice is maintained by a Notch–Collagen V–CALCR signalling pathway that is activated and sustained in a cell-autonomous fashion.

  • Meryem B. Baghdadi
  • , David Castel
  •  & Philippos Mourikis

• Letter | 30 November 2016

  Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

  Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a known inhibitory effect on satellite cell function and muscle regeneration in aged mice.

  • Simon Schwörer
  • , Friedrich Becker
  •  & K. Lenhard Rudolph

• Letter | 25 May 2014

  mTORC1 controls the adaptive transition of quiescent stem cells from G₀ to G_Alert

  A mouse study reveals that the stem cell quiescent state is composed of two distinct phases, G₀ and G_Alert; stem cells reversibly transition between these two phases in response to systemic environmental stimuli acting through the mTORC1 pathway.

  • Joseph T. Rodgers
  • , Katherine Y. King
  •  & Thomas A. Rando

• Article | 12 February 2014

  Geriatric muscle stem cells switch reversible quiescence into senescence

  This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16^INK4a is identified as a common feature of senescent satellite cells.

  • Pedro Sousa-Victor
  • , Susana Gutarra
  •  & Pura Muñoz-Cánoves

• Article | 26 September 2012

  The aged niche disrupts muscle stem cell quiescence

  The expression of fibroblast growth factor in aged muscle fibre, the muscle stem cell niche, is shown to cause satellite cells to lose the capacity for self-renewal, and is thus an age-dependent change that directly influences stem cell quiescence and function.

  • Joe V. Chakkalakal
  • , Kieran M. Jones
  •  & Andrew S. Brack

• Letter | 23 February 2012

  Maintenance of muscle stem-cell quiescence by microRNA-489

  Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

  • Tom H. Cheung
  • , Navaline L. Quach
  •  & Thomas A. Rando