RNA (ribonucleic acid) is a nucleic acid polymer where the carbohydrate is ribose. RNA is generally single-stranded, as DNA is transcribed by RNA polymerases into mRNA (messenger RNA), which is read by ribosomes to generate protein (translation). Biologically active RNAs, including transport, ribosomal and small nuclear RNA (tRNA, rRNA, snRNAs) fold into unique structures guided by complementary pairing between nucleotide bases.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    This study shows that circular RNAs that contain double-stranded regions can modulate innate immunity by inhibiting the pattern recognition receptor protein kinase R (PKR).

    • Alexandra Flemming
  • News and Views |

    RNAs perform diverse cellular functions that are mediated at least in part by their structure. However, how RNA structure changes throughout the RNA lifecycle and how these changes affect RNA function remain incompletely understood. A detailed in vivo characterization of RNA structure in various cellular subcompartments now provides insights into how RNA structural changes influence translation, RNA decay, protein binding and RNA modification.

    • Angela M Yu
    •  & Julius B. Lucks
  • News and Views |

    The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs.

    • Richard A. Padgett
  • News and Views |

    Phase separation underlies the formation of cellular membrane-less organelles. A new report identifies deacetylation at lysine residues of intrinsically disordered protein regions to drive liquid droplet formation in vitro and stress granule maturation inside cells.

    • Alessia Ruggieri
    •  & Georg Stoecklin