sc-SPORT offers a way to probe RNA structure at the single-cell level. It reveals cell-to-cell heterogeneity in RNA folding.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Su, Z. et al. Proc. Natl Acad. Sci. USA 115, 12170–12175 (2018).
Sun, L. et al. Nat. Struct. Mol. Biol. 26, 322–330 (2019).
Christy, T. W. et al. Biochemistry 60, 1971–1982 (2021).
Jolley, E. A., Yakhnin, H., Tack, D. C., Babitzke, P. & Bevilacqua, P. C. RNA 29, 1365–1378 (2023).
Zubradt, M. et al. Nature 14, 75–82 (2017).
Spasic, A., Assmann, S. M., Bevilacqua, P. C. & Mathews, D. H. Nucleic Acids Res. 46, 314–323 (2018).
Wang, J. et al. Nat. Methods https://doi.org/10.1038/s41592-023-02128-y (2024).
Smola, M. J. & Weeks, K. M. Nat. Protoc. 13, 1181–1195 (2018).
Yamagami, R., Sieg, J. P., Assmann, S. M. & Bevilacqua, P. C. Proc. Natl Acad. Sci. USA 119, e2201237119 (2022).
Flynn, R. A. et al. Nat. Protoc. 11, 273–290 (2016).
Acknowledgements
This work was supported by funds from the National Institute of Health grant R35- GM127064 (P.C.B.).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Jolley, E.A., Bevilacqua, P.C. Single-cell probing of RNA structure. Nat Methods 21, 377–378 (2024). https://doi.org/10.1038/s41592-024-02178-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41592-024-02178-w