Activation of innate immunity has been linked to the progression of type 1 diabetes. A study now shows that overexpression of METTL3, a writer protein of the m6A machinery that modifies mRNA, restrains interferon-stimulated genes when expressed in pancreatic β-cells, identifying it as a promising therapeutic target.
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Krishnamurthy, B., Thomas, H.E. METTL3 restrains autoimmunity in β-cells. Nat Cell Biol 26, 321–322 (2024). https://doi.org/10.1038/s41556-024-01352-8
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DOI: https://doi.org/10.1038/s41556-024-01352-8