Interactions between RNA and RNA-binding proteins (RBPs) define the fate and function of every RNA molecule. We present TREX, or targeted RNase H-mediated extraction of crosslinked RBPs, an efficient and accurate method to unbiasedly reveal the protein interactors of specific regions of RNAs isolated from living cells.
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References
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This is a summary of: Dodel, M. et al. TREX reveals proteins that bind to specific RNA regions in living cells. Nat. Methods https://doi.org/10.1038/s41592-024-02181-1 (2024).
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TREX identifies region-specific protein interactors of RNA molecules. Nat Methods 21, 381–382 (2024). https://doi.org/10.1038/s41592-024-02182-0
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DOI: https://doi.org/10.1038/s41592-024-02182-0
