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Phase separation

Mesoscale condensates organize the cytoplasm

Nature Cell Biology volume 26, pages 310–312 (2024)Cite this article

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Biomolecular condensates are recognized for their ability to compartmentalize the cytoplasm without bounding membranes, but the degree to which they organize the cytoplasm has not been clear. A new study reveals that condensates at a scale of 100 nm are responsible for the organization of at least 18% of the cytoplasmic proteome.

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Fig. 1: Cytoplasmic proteins are organized by membrane-bound organelles and BMCs.

References

  1. Keber, F. C. et al. Nat. Cell. Biol. https://doi.org/10.1038/s41556-024-01363-5 (2024).

  2. Lyon, A. S., Peeples, W. B. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. 22, 215–235 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. McSwiggen, D. T., Mir, M., Darzacq, X. & Tjian, R. Genes Dev. 33, 1619–1634 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yoshida, S. R., Maity, B. K. & Chong, S. J. Phys. Chem. B 127, 4165–4173 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rauscher, S. & Pomès, R. eLife 6, e26526 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Forman-Kay, J. D., Ditlev, J. A., Nosella, M. L. & Lee, H. O. RNA 28, 36–47 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wang, Z., Lou, J. & Zhang, H. J. Biol. Chem. 298, 101782 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lee, D. S. W. et al. Nat. Phys. 19, 586–596 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ditlev, J. A., Case, L. B. & Rosen, M. K. J. Mol. Biol. 430, 4666–4684 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Case, L. B., Ditlev, J. A. & Rosen, M. K. Annu. Rev. Biophys. 48, 465–494 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Mittag, T. & Pappu, R. V. Mol. Cell 82, 2201–2214 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Roden, C. & Gladfelter, A. S. Nat. Rev. Mol. Cell Biol. 22, 183–195 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Snead, W. T. et al. Nat. Cell Biol. 24, 461–470 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Hardenberg, M. et al. Proc. Natl. Acad. Sci. 117, 33254–33262 (2020).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  15. Azaldegui, C. A., Vecchiarelli, A. G. & Biteen, J. S. Biophys. J. 120, 1123–1138 (2021).

    Article  ADS  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Programs in Molecular Medicine and Cell Biology, Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    Leshani Ahangama Liyanage & Jonathon A. Ditlev

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  1. Leshani Ahangama Liyanage
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  2. Jonathon A. Ditlev
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Correspondence to Jonathon A. Ditlev.

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J.A.D. is an advisor for Dewpoint Therapeutics. L.A.L. declares no competing interests.

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Ahangama Liyanage, L., Ditlev, J.A. Mesoscale condensates organize the cytoplasm. Nat Cell Biol 26, 310–312 (2024). https://doi.org/10.1038/s41556-023-01331-5

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