Featured
-
-
News & Views |
Lymphatics drain nanoparticles from tumours
Lymphatic vessels within and near to tumours facilitate nanoparticle transport out of tumours, with ramifications in the design and implementation of next-generation clinical cancer nanomedicines.
- Meghan J. O’Melia
- & Susan N. Thomas
-
Article |
Accurate computational design of three-dimensional protein crystals
The process of protein crystallization is poorly understood and difficult to program through the primary sequence. Here the authors develop a computational approach to designing three-dimensional protein crystals with prespecified lattice architectures with high accuracy.
- Zhe Li
- , Shunzhi Wang
- & David Baker
-
Article
| Open Access
Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo
Magneto-gas vesicles, protein nanostructures with enhanced ultrasound signal and sensitivity, enable the non-invasive, long-term and quantitative monitoring of the mechanics of three-dimensional tissues and animals.
- Whee-Soo Kim
- , Sungjin Min
- & Jinwoo Cheon
-
Article |
Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy
A curvature-sensing antiviral peptide is repurposed to disrupt tumour-derived exosomes and used in combination with immune checkpoint blockade cancer therapy.
- Sol Shin
- , Hyewon Ko
- & Jae Hyung Park
-
News & Views |
Immunostimulatory nanoparticles go viral
A polymeric nanoparticle adjuvant containing a Toll-like receptor 7 agonist elicits broad protection against viral challenges.
- Jorge Huete-Carrasco
- & Ed C. Lavelle
-
News & Views |
Inhalable mRNA nanoparticles
A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species.
- Ronnie H. Fang
- & Liangfang Zhang
-
News & Views |
Exploiting endothelial transcytosis to reach into the brain
Targeting P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical medulloblastoma tumour models.
- Lin Wang
- & Stefan Wilhelm
-
Article
| Open Access
P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis
Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma.
- Daniel E. Tylawsky
- , Hiroto Kiguchi
- & Daniel A. Heller
-
News & Views |
Multi-channel control of fruit fly behaviour
Fruit flies injected with magnetic nanoparticles and genetically modified to sensitize neural circuits to the rate of change in temperature have enabled subsecond behavioural responses to magnetic stimuli and multi-channel magnetic control.
- Michael G. Christiansen
- & Simone Schuerle
-
Article |
Subsecond multichannel magnetic control of select neural circuits in freely moving flies
Here the authors describe a method for remote magnetothermal stimulation of neurons that achieves subsecond behavioural responses in Drosophila fruit flies by combining magnetic nanoparticles with TRPA1-A, a rate-sensitive thermoreceptor. Tuning the properties of magnetic nanoparticles to respond to different magnetic field strengths and frequencies enables multichannel thermal magnetogenetic stimulation.
- Charles Sebesta
- , Daniel Torres Hinojosa
- & Jacob T. Robinson
-
News & Views |
Wireless neuromodulation with porous silicon
Wireless optoelectronic devices are fabricated by controlling the porosity of p-type silicon, enabling in vivo efficient, non-genetic optoelectronic modulation of peripheral nerve activity.
- Silvestro Micera
- & Eugenio Redolfi Riva
-
Article |
Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues
Fabrication of semiconductor heterojunctions typically involves a complex process and often leads to bioincompatibility. Here, the authors propose a porous heterojunction in p-type silicon via simple stain etching at ambient conditions, and apply it in optically induced biomodulation.
- Aleksander Prominski
- , Jiuyun Shi
- & Menahem Y. Rotenberg
-
Article |
Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection
Early cancer detection typically involves invasive biopsies. Here the authors designed nanosensors that are depolymerized by disease-associated enzymes in vivo to produce fluorescent urinary signals for non-invasive early diagnosis.
- Jiaguo Huang
- , Xiaona Chen
- & Kanyi Pu
-
News & Views |
A ‘Swiss army knife’ probe for metastatic cancers
A nanosensor probe that combines a tumour-targeting peptide, a diagnostic reporter and an imaging contrast agent enables early diagnosis, precision imaging, disease stratification and downstream therapeutic response monitoring of metastatic cancer.
- Matthew Bogyo
-
Editorial |
A molecular jack-of-all-trades
DNA is much more than the genetic information it carries. It is a versatile material for creating systems with tailor-made functionalities that are having an important impact in emerging technologies.
-
News & Views |
Nanocages for virus inhibition
Elaborately designed DNA icosahedral shells cage intact virions to effectively protect host cells from viral infections.
- Neha Chauhan
- & Xing Wang
-
Article |
UItra-low friction and edge-pinning effect in large-lattice-mismatch van der Waals heterostructures
MoS2/graphite and MoS2/h-BN interfaces are shown to have ultra-low friction coefficients, whereas edges and interface steps mainly contribute to the friction force.
- Mengzhou Liao
- , Paolo Nicolini
- & Guangyu Zhang
-
News & Views |
Remote modulation of neuronal cells in the brain
The combination of multicomponent magnetic nanoparticles and a mechanosensitive ion channel has been shown to achieve fast magnetomechanical stimulation of neurons within the brain.
- Rahul Mushi
- & Arnd Pralle
-
Article |
Programmable icosahedral shell system for virus trapping
Programmable triangular DNA blocks self-assemble into distinct icosahedral shells with specific geometry and apertures that can encapsulate viruses and decrease viral infection.
- Christian Sigl
- , Elena M. Willner
- & Hendrik Dietz
-
Article |
Integrated computer-aided engineering and design for DNA assemblies
An approach integrating molecular dynamics-based computer-aided engineering with computer-aided design allows for the rapid construction of large three-dimensional DNA assemblies and control over their geometry, mechanics and dynamics.
- Chao-Min Huang
- , Anjelica Kucinic
- & Carlos E. Castro
-
Article |
Three-dimensional nanolithography guided by DNA modular epitaxy
Epitaxially grown 3D DNA masks with prescribed geometry, pitch and size improve the resolution of reactive ion etching-based nanolithography, scaling the line pitch down to 16.2 nm and the critical dimension size to 7.2 nm.
- Jie Shen
- , Wei Sun
- & Peng Yin
-
Article |
Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals
A magnetic torque actuator has been developed and is capable of modulation of neurons expressing the mechanosensitive ion channel, Piezo1, resulting in long-distance control of locomotion of mice.
- Jung-uk Lee
- , Wookjin Shin
- & Jinwoo Cheon
-
Article |
The dose threshold for nanoparticle tumour delivery
Efficient nanoparticle delivery into tumours has been a challenge in the field. It is now shown that the efficiency can be improved substantially when the dose breaches a specific threshold.
- Ben Ouyang
- , Wilson Poon
- & Warren C. W. Chan
-
News & Views |
Learning with brain chemistry
Organic neuromorphic devices are now able to take direct input from cellular neurotransmitter release.
- Tobias Cramer
-
Article |
Tracking intracellular forces and mechanical property changes in mouse one-cell embryo development
Mechanical properties and forces sculpt the behaviour of cells in living organisms. Silicon-based nanochips implanted into mouse one-cell embryos have been used to reveal mechanical changes during the early onset of embryonic development.
- Marta Duch
- , Núria Torras
- & Anthony C. F. Perry
-
Article |
Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy
An anticancer agent, olsalazine, conjugated to a cell-penetrating peptide has been synthesized and shows the ability to self-assemble intracellularly by the tumour-associated enzyme furin, with the potential for tumour therapy and chemical exchange saturation transfer magnetic resonance imaging in vivo.
- Yue Yuan
- , Jia Zhang
- & Jeff W. M. Bulte
-
News & Views |
CRISPR genome editing in stem cells turns to gold
Hematopoietic stem and progenitor cells have been engineered using gold nanoformulations conjugated with CRISPR capable of targeting two distinct genomic loci of therapeutic interest, with potential engraftment in humanized mouse models.
- Aravind Asokan
-
Article |
Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis
Imbalance of the gut microbiome has been implicated in numerous human diseases. Nanoparticles have now been designed to target colitis by modulating the gut microbiome, local innate immune response and restoration of the intestinal barrier function.
- Yonghyun Lee
- , Kohei Sugihara
- & James J. Moon
-
Letter |
Cellular nanoscale stiffness patterns governed by intracellular forces
High-spatial-resolution mechanical imaging reveals that intracellular forces generate cellular nanoscale stiffness patterns.
- Nicola Mandriota
- , Claudia Friedsam
- & Ozgur Sahin
-
Article |
Shape-based separation of synthetic microparticles
A fluorescence-activated cell sorter is used to purify microparticles from colloidal mixtures.
- Peter L. Mage
- , Andrew T. Csordas
- & H. Tom Soh
-
Article |
Highly mechanosensitive ion channels from graphene-embedded crown ethers
Tuning ionic permeation across nanoscale pores is important for areas ranging from nanofluidic computing to drug delivery. Complex formation between crown ethers and dissolved metal ions is used to demonstrate graphene-based ion channels with high mechanosensitivity.
- A. Fang
- , K. Kroenlein
- & A. Smolyanitsky
-
News & Views |
A tale about square dancers and maze runners
Single-particle tracking of nanoparticles dispersed in the cytoplasm of living cells shows that non-specific interactions with the intracellular environment are the major contributors for the anomalous diffusion characteristics of intracellular motion.
- Matthias Weiss
-
Article |
Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells
Nanoparticle diffusion in the cytoplasm of living cells strongly deviates from random motion. Single-particle tracking analysis show that this is due to non-specific interactions with intracellular components.
- Fred Etoc
- , Elie Balloul
- & Mathieu Coppey
-
News & Views |
Gas vesicles as collapsible MRI contrast agents
Microbial gas vesicles have been developed for use as MRI contrast agents whose contrast can be inactivated by applying ultrasound waves to collapse the vesicles.
- Jeff W. M. Bulte
-
Article |
Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures
Gas-filled vesicles derived from photosynthetic microbes are shown to elicit magnetic resonance imaging contrast in vitro and in vivo with the potential for acoustically modulated multiplexing and molecular sensing.
- George J. Lu
- , Arash Farhadi
- & Mikhail G. Shapiro
-
News & Views |
Instant integrin mechanosensing
Single-cell force spectroscopy reveals rapid, biphasic integrin activation and reinforcement of cell–matrix bonds during the initial steps of fibroblast adhesion.
- Ning Wang
-
Article |
Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second
Integrins play an important role in the adhesion of cells to their matrix. Here, the authors investigate how fibroblasts respond to mechanical loads, at the onset of cell adhesion to fibronectin, in distinct phases that are modulated by integrins.
- Nico Strohmeyer
- , Mitasha Bharadwaj
- & Daniel J. Müller
-
Article |
Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics
A microfluidics method to generate giant, copolymer-stabilized liposomes is presented. These vesicles are functionalized with distinct proteins to recapitulate cellular processes.
- Marian Weiss
- , Johannes Patrick Frohnmayer
- & Joachim P. Spatz
-
News & Views |
Nanostructure evolution
DNA origami nanostructures were utilized to replicate a seed pattern that resulted in the growth of populations of nanostructures. Exponential growth could be controlled by environmental conditions depending on the preferential requirements of each population.
- Friedrich C. Simmel
-
News & Views |
Intrinsic nanoscale patterning
A method to realize regular patterns with nanometre precision during the synthesis of PtSe2 and CuSe monolayers has been developed.
- Joseph W. Lyding
-
Article |
Nitroaromatic detection and infrared communication from wild-type plants using plant nanobionics
Plants can be engineered to serve as self-powered pre-concentrators and autosamplers of analytes in ambient groundwater and as infrared communication platforms that can send information to a smartphone.
- Min Hao Wong
- , Juan P. Giraldo
- & Michael S. Strano
-
Article |
Mechanism of hard-nanomaterial clearance by the liver
The blood clearance mechanism, by the liver, of administered hard nanomaterials is reported in relation to blood flow dynamics, organ microarchitecture and cellular phenotype.
- Kim M. Tsoi
- , Sonya A. MacParland
- & Warren C. W. Chan
-
Article |
Detection and imaging of quorum sensing in Pseudomonas aeruginosa biofilm communities by surface-enhanced resonance Raman scattering
Nanostructured plasmonic substrates are used for in situ, label-free detection, by surface-enhanced resonance Raman scattering spectroscopy, of quorum sensing in growing Pseudomonas aeruginosa biofilms.
- Gustavo Bodelón
- , Verónica Montes-García
- & Luis M. Liz-Marzán
-
Review Article |
Mixed-dimensional van der Waals heterostructures
This Review discusses the different, state-of-the-art applications of heterostructures containing at least one layer of a two-dimensional (2D) material, combined with 0D, 1D and 3D nano-objects.
- Deep Jariwala
- , Tobin J. Marks
- & Mark C. Hersam
-
Article |
Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model
A hydrogel patch delivering a combination of gene, drug and phototherapy leads to complete tumour remission and the absence of tumour recurrence in a colon cancer mouse model.
- João Conde
- , Nuria Oliva
- & Natalie Artzi
-
News & Views |
Growing gold nanoprisms with light
An adsorbed polymer directs the photochemical growth of colloidal Au single-crystal nanoprisms following visible metal excitation.
- Louis Brus
-
Article |
Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces
A biocompatible and biodegradable mesostructured form of silicon is used to make lipid-bilayer-supported bioelectric interfaces that can optically modulate the electrophysiology of single dorsal root ganglia neurons.
- Yuanwen Jiang
- , João L. Carvalho-de-Souza
- & Bozhi Tian
-
Article |
Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes
An ultra-flexible cylindrical mesh embedding multiple electrodes bending away from the device is used to probe rodents’ neural activity in vivo. This geometry improves the neuron–probe contact and reduces tissue response in chronic applications.
- Chong Xie
- , Jia Liu
- & Charles M. Lieber
-
An intelligent DNA nanodevice for precision thrombolysis
Forceful growth