Featured
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Article |
UItra-low friction and edge-pinning effect in large-lattice-mismatch van der Waals heterostructures
MoS2/graphite and MoS2/h-BN interfaces are shown to have ultra-low friction coefficients, whereas edges and interface steps mainly contribute to the friction force.
- Mengzhou Liao
- , Paolo Nicolini
- & Guangyu Zhang
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Letter |
Cellular nanoscale stiffness patterns governed by intracellular forces
High-spatial-resolution mechanical imaging reveals that intracellular forces generate cellular nanoscale stiffness patterns.
- Nicola Mandriota
- , Claudia Friedsam
- & Ozgur Sahin
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News & Views |
Instant integrin mechanosensing
Single-cell force spectroscopy reveals rapid, biphasic integrin activation and reinforcement of cell–matrix bonds during the initial steps of fibroblast adhesion.
- Ning Wang
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Article |
Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second
Integrins play an important role in the adhesion of cells to their matrix. Here, the authors investigate how fibroblasts respond to mechanical loads, at the onset of cell adhesion to fibronectin, in distinct phases that are modulated by integrins.
- Nico Strohmeyer
- , Mitasha Bharadwaj
- & Daniel J. Müller
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News & Views |
Nanostructure evolution
DNA origami nanostructures were utilized to replicate a seed pattern that resulted in the growth of populations of nanostructures. Exponential growth could be controlled by environmental conditions depending on the preferential requirements of each population.
- Friedrich C. Simmel
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Article |
Interplay of matrix stiffness and protein tethering in stem cell differentiation
Recent work has proposed that both protein tethering to the extracellular matrix and matrix porosity can regulate stem cell differentiation. It is now shown that differentiation is driven by matrix stiffness independently of tethering and porosity.
- Jessica H. Wen
- , Ludovic G. Vincent
- & Adam J. Engler