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A ‘Swiss army knife’ probe for metastatic cancers

Nature Materials volume 20, pages 1312–1314 (2021)Cite this article

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A nanosensor probe that combines a tumour-targeting peptide, a diagnostic reporter and an imaging contrast agent enables early diagnosis, precision imaging, disease stratification and downstream therapeutic response monitoring of metastatic cancer.

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Fig. 1: A multimodal imaging probe for detection and monitoring of metastatic cancers.

References

  1. Ofori, L. O. et al. ACS Chem. Biol. 10, 1977–1988 (2015).

    Article  CAS  Google Scholar 

  2. Widen, J. C. et al. Nat. Biomed. Eng. 5, 264–277 (2021).

    Article  CAS  Google Scholar 

  3. Hunt, J. F., Rath, P., Rothschild, K. J. & Engelman, D. M. Biochemistry 36, 15177–15192 (1997).

    Article  CAS  Google Scholar 

  4. Weerakkody, D. et al. Proc. Natl Acad. Sci. USA 110, 5834–5839 (2013).

    Article  CAS  Google Scholar 

  5. Hao, L. et al. Nat. Mater. https://doi.org/10.1038/s41563-021-01042-y (2021).

  6. Buss, C. G., Dudani, J. S., Akana, R. T. K., Fleming, H. E. & Bhatia, S. N. EBioMedicine 38, 248–256 (2018).

    Article  Google Scholar 

  7. Dudani, J. S., Ibrahim, M., Kirkpatrick, J., Warren, A. D. & Bhatia, S. N. Proc. Natl Acad. Sci. USA 115, 8954–8959 (2018).

    Article  CAS  Google Scholar 

  8. Kirkpatrick, J. D. et al. Sci. Transl. Med. 12, eaaw0262 (2020).

    Article  CAS  Google Scholar 

  9. Kwong, G. A. et al. Nat. Biotechnol. 31, 63–70 (2013).

    Article  CAS  Google Scholar 

  10. Warren, A. D. et al. J. Am. Chem. Soc. 136, 13709–13714 (2014).

    Article  CAS  Google Scholar 

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  1. Departments of Pathology and Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA

    Matthew Bogyo

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  1. Matthew Bogyo
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Correspondence to Matthew Bogyo.

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Competing interests

M.B. is a founder and consultant for Akrotome Imaging Inc. and is a consultant at Vergent Bioscience. Both companies are developing optical contrast agents that target lysosomal cysteine protease for imaging tumours during surgery.

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Bogyo, M. A ‘Swiss army knife’ probe for metastatic cancers. Nat. Mater. 20, 1312–1314 (2021). https://doi.org/10.1038/s41563-021-01105-0

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