Imaging articles within Nature

Featured

  • News Feature |

    Functional magnetic resonance imaging is growing from showy adolescence into a workhorse of brain imaging.

    • Kerri Smith

  • News |

    Critics take a hard look at ankylography, a proposed method for revealing molecular structures from single pictures.

    • Eugenie Samuel Reich

  • News |

    Imaging technique could show how dozens of bacteria interact in the human mouth.

    • Monya Baker

  • News & Views |

    An innovative marriage of techniques, combining the principles of common protein pull-down assays with single-molecule fluorescence microscopy, opens up new ways of visualizing cellular protein complexes. See Article p.484

    • Philip Tinnefeld

  • Letter |

    The start-up of the new femtosecond hard X-ray laser facility in Stanford, the Linac Coherent Light Source, has brought high expectations for a new era for biological imaging. The intense, ultrashort X-ray pulses allow diffraction imaging of small structures before radiation damage occurs. This new capability is tested for the problem of imaging a non-crystalline biological sample. Images of mimivirus are obtained, the largest known virus with a total diameter of about 0.75 micrometres, by injecting a beam of cooled mimivirus particles into the X-ray beam. The measurements indicate no damage during imaging and prove the concept of this imaging technique.

    • M. Marvin Seibert
    • , Tomas Ekeberg
    •  & Janos Hajdu

  • Brief Communications Arising |

    • Jin Hyung Lee
    • , Remy Durand
    •  & Karl Deisseroth

  • News & Views |

    Nanoparticles that generate light through a mechanism known as second harmonic generation have been used to image live tissue. The particles overcome many problems associated with fluorescent probes for bioimaging.

    • Bruce E. Cohen

  • Letter |

    Newly synthesized messenger RNA is exported from the nucleus through nuclear pores. Here, a new imaging and tracking method has been developed to study the kinetics of mRNA export, with 20-ms time-precision and 26-nm spatial precision. A three-step model for export is presented, comprising docking, transport and release. Notably, mRNAs can move bi-directionally through the pore complex.

    • David Grünwald
    •  & Robert H. Singer

  • Letter |

    Blood oxygenation level-dependent (BOLD) signals are the basis for much of the work on which regions of the human brain are active during particular tasks or behaviours, but there is controversy over their source and interpretation. Here a combination of optogenetics and BOLD signal monitoring shows that specific excitatory neurons within a mixed population are sufficient to produce positive BOLD signals, and could be used to map connections.

    • Jin Hyung Lee
    • , Remy Durand
    •  & Karl Deisseroth

  • News & Views |

    Analysis of a selected class of neuron in the brains of live animals using functional magnetic resonance imaging (fMRI) opens the door to mapping genetically specified neural circuits.

    • David A. Leopold

  • Article |

    High-throughput microscopy combined with gene silencing by RNA interference is a powerful method for studying gene function. Here, a genome-wide method is presented for phenotypic screening of each of the ∼21,000 human protein-coding genes, using two-day imaging of dividing cells with fluorescently labelled chromosomes. The method enabled the identification of hundreds of genes involved in biological functions such as cell division, migration and survival.

    • Beate Neumann
    • , Thomas Walter
    •  & Jan Ellenberg

  • News Feature |

    Last year, functional magnetic resonance imaging made its debut in court. Virginia Hughes asks whether the technique is ready to weigh in on the fate of murderers.

    • Virginia Hughes

  • Article |

    A new strategy is presented to accurately profile the activity of human genes in endocytosis by combining genome-wide RNAi, automated high-resolution confocal microscopy and quantitative multi-parametric image analysis. Several novel components of endocytosis and endosome trafficking were uncovered; a systems analysis further revealed that the cell regulates the number, size and concentration of cargo within endosomes.

    • Claudio Collinet
    • , Martin Stöter
    •  & Marino Zerial

  • Technology Feature |

    As the techniques for imaging whole animals become more sophisticated, researchers are able to get a clearer picture of what is going on inside. Monya Baker looks at the options available.

    • Monya Baker

  • Letter |

    De novo emergence of phenotypically defined haematopoietic stem cells (Sca1+, c kit+, CD41+) directly from ventral aortic haemogenic endothelial cells is shown in mice. Although the study did not visualize live embryos, it instead developed a dissection procedure to visualize the deeply located aorta.

    • Jean-Charles Boisset
    • , Wiggert van Cappellen
    •  & Catherine Robin

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