Fluorescence imaging articles within Nature

Featured

  • Article
    | Open Access

    Measurements of signal propagation in more than 23,000 pairs of neurons from nematode worms show that predictions of neural function made on the basis of anatomy are often incorrect, in part owing to the effects of extrasynaptic signalling.

    • Francesco Randi
    • , Anuj K. Sharma
    •  & Andrew M. Leifer
  • Article |

    High-throughput DNA or RNA labelling with optimized Oligopaints (HiDRO) reveals more than 300 factors that influence genome folding during interphase, including 43 genes that were validated as either increasing or decreasing interactions between topologically associating domains.

    • Daniel S. Park
    • , Son C. Nguyen
    •  & Eric F. Joyce
  • Article
    | Open Access

    Spatial-ATAC-seq—spatially resolved chromatin accessibility profiling of tissue sections using next-generation sequencing—delineated tissue-region-specific epigenetic landscapes in mouse embryos and identified gene regulators involved in the development of the central nervous system and the lymphoid tissue.

    • Yanxiang Deng
    • , Marek Bartosovic
    •  & Rong Fan
  • Article |

    A combination of multiview imaging, structured illumination, reconstruction algorithms and deep-learning predictions realizes spatial- and temporal-resolution improvements in fluorescence microscopy to produce super-resolution images from diffraction-limited input images.

    • Yicong Wu
    • , Xiaofei Han
    •  & Hari Shroff
  • Article |

    The net PKA activities in each class of spiny projection neuron in the nucleus accumbens of the mouse are dichotomously modulated by asynchronous positive and negative dopamine signals during different phases of learning.

    • Suk Joon Lee
    • , Bart Lodder
    •  & Bernardo L. Sabatini
  • Article |

    Neurons in the canary premotor cortex homologue encode past song phrases and transitions, carrying information relevant to future choice of phrases as ‘hidden states’ during song.

    • Yarden Cohen
    • , Jun Shen
    •  & Timothy J. Gardner
  • Article |

    Fluorescence-based polysomnography in zebrafish reveals two major sleep signatures that share features with those of amniotes, which suggests that common neural sleep signatures emerged in the vertebrate brain over 450 million years ago.

    • Louis C. Leung
    • , Gordon X. Wang
    •  & Philippe Mourrain
  • Letter |

    Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.

    • Lawrence Fourgeaud
    • , Paqui G. Través
    •  & Greg Lemke
  • Letter |

    Genetically encoded probes for the non-peptidic morphogen retinoic acid allow the quantitative measurement of physiological RA concentration in vivo; the results support the source–sink diffusion model of morphogen dynamics proposed by Francis Crick in 1970.

    • Satoshi Shimozono
    • , Tadahiro Iimura
    •  & Atsushi Miyawaki
  • News |

    Imaging technique could show how dozens of bacteria interact in the human mouth.

    • Monya Baker
  • News & Views |

    An innovative marriage of techniques, combining the principles of common protein pull-down assays with single-molecule fluorescence microscopy, opens up new ways of visualizing cellular protein complexes. See Article p.484

    • Philip Tinnefeld