Time-lapse imaging articles within Nature

Featured

• Article | 05 February 2020

  Live-animal imaging of native haematopoietic stem and progenitor cells

  A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.

  • Constantina Christodoulou
  • , Joel A. Spencer
  •  & Fernando D. Camargo

• Article | 08 January 2020

  Coupling delay controls synchronized oscillation in the segmentation clock

  Monitoring cells of the mouse presomitic mesoderm using the Achilles reporter fused to HES7 sheds light on the mechanisms that underpin synchronous oscillations in the expression of clock genes between neighbouring cells.

  • Kumiko Yoshioka-Kobayashi
  • , Marina Matsumiya
  •  & Ryoichiro Kageyama

• Letter | 31 May 2017

  Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity

  The mycobacterial protein LamA functions as an inhibitor of cell wall synthesis at the nascent cell pole, contributing to asymmetry in polar growth, and could represent a much-needed target for the development of anti-tuberculosis therapies.

  • E. Hesper Rego
  • , Rebecca E. Audette
  •  & Eric J. Rubin

• Article | 01 April 2010

  Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

  High-throughput microscopy combined with gene silencing by RNA interference is a powerful method for studying gene function. Here, a genome-wide method is presented for phenotypic screening of each of the ∼21,000 human protein-coding genes, using two-day imaging of dividing cells with fluorescently labelled chromosomes. The method enabled the identification of hundreds of genes involved in biological functions such as cell division, migration and survival.

  • Beate Neumann
  • , Thomas Walter
  •  & Jan Ellenberg

• News | 31 March 2010

  Lights, camera, action for cells

  Time-lapse films reveal the functions of human genes.

  • Janelle Weaver