Oncology

Definition

Oncology is the branch of medicine that deals with the diagnosis and treatment of cancer. It includes medical oncology (the use of chemotherapy, hormone therapy, and other drugs to treat cancer), radiation oncology (the use of radiation therapy to treat cancer), and surgical oncology (the use of surgery and other procedures to treat cancer).

Featured

Latest Research and Reviews

  • Research |

    Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to identify those with DNA-repair deficiencies that make the tumor more likely to respond to therapies based on PARP inhibitors or platinum. In contrast, oncogenic mutations in several other DNA-repair genes do not generate these patterns.

    • Paz Polak
    • , Jaegil Kim
    • , Lior Z Braunstein
    • , Rosa Karlic
    • , Nicholas J Haradhavala
    • , Grace Tiao
    • , Daniel Rosebrock
    • , Dimitri Livitz
    • , Kirsten Kübler
    • , Kent W Mouw
    • , Atanas Kamburov
    • , Yosef E Maruvka
    • , Ignaty Leshchiner
    • , Eric S Lander
    • , Todd R Golub
    • , Aviad Zick
    • , Alexandre Orthwein
    • , Michael S Lawrence
    • , Rajbir N Batra
    • , Carlos Caldas
    • , Daniel A Haber
    • , Peter W Laird
    • , Hui Shen
    • , Leif W Ellisen
    • , Alan D D'Andrea
    • , Stephen J Chanock
    • , William D Foulkes
    •  & Gad Getz
  • Research |

    Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.

    • Sarah J. Horton
    • , George Giotopoulos
    • , Haiyang Yun
    • , Shabana Vohra
    • , Olivia Sheppard
    • , Rachael Bashford-Rogers
    • , Mamunur Rashid
    • , Alexandra Clipson
    • , Wai-In Chan
    • , Daniel Sasca
    • , Loukia Yiangou
    • , Hikari Osaki
    • , Faisal Basheer
    • , Paolo Gallipoli
    • , Natalie Burrows
    • , Ayşegül Erdem
    • , Anastasiya Sybirna
    • , Sarah Foerster
    • , Wanfeng Zhao
    • , Tonci Sustic
    • , Anna Petrunkina Harrison
    • , Elisa Laurenti
    • , Jessica Okosun
    • , Daniel Hodson
    • , Penny Wright
    • , Ken G. Smith
    • , Patrick Maxwell
    • , Jude Fitzgibbon
    • , Ming Q. Du
    • , David J. Adams
    •  & Brian J. P. Huntly
  • Research |

    Elizabeth Perlman and colleagues use genome-wide sequencing, RNA expression, DNA copy number and methylation analyses to characterize the genomic landscape of Wilms tumors. Their integrated analyses implicate two major classes of genetic changes in Wilms tumors that preserve the progenitor state and/or interrupt normal kidney development.

    • Samantha Gadd
    • , Vicki Huff
    • , Amy L Walz
    • , Ariadne H A G Ooms
    • , Amy E Armstrong
    • , Daniela S Gerhard
    • , Malcolm A Smith
    • , Jaime M Guidry Auvil
    • , Daoud Meerzaman
    • , Qing-Rong Chen
    • , Chih Hao Hsu
    • , Chunhua Yan
    • , Cu Nguyen
    • , Ying Hu
    • , Leandro C Hermida
    • , Tanja Davidsen
    • , Patee Gesuwan
    • , Yussanne Ma
    • , Zusheng Zong
    • , Andrew J Mungall
    • , Richard A Moore
    • , Marco A Marra
    • , Jeffrey S Dome
    • , Charles G Mullighan
    • , Jing Ma
    • , David A Wheeler
    • , Oliver A Hampton
    • , Nicole Ross
    • , Julie M Gastier-Foster
    • , Stefan T Arold
    •  & Elizabeth J Perlman