Gastroenterology is a medical specialty focusing on the structure, function, pathology and disorders of the gastrointestinal system.

Latest Research and Reviews

  • Reviews |

    Host-directed therapy (HDT) aims to interfere with host cell factors that are required by a pathogen for replication or persistence. In this Review, Kaufmann et al. describe recent progress in the development of HDTs for the treatment of viral and bacterial infections and the challenges in bringing these approaches to the clinic.

    • Stefan H. E. Kaufmann
    • , Anca Dorhoi
    • , Richard S. Hotchkiss
    •  & Ralf Bartenschlager
  • Reviews |

    Children with severe malnutrition (which includes severe wasting and kwashiorkor) have an elevated risk of serious illness and death, primarily from acute infectious diseases. In this Primer, the authors describe the multifactorial aetiology of severe malnutrition and the efforts needed to meet the United Nations’ Sustainable Development Goal of zero hunger.

    • Zulfiqar A. Bhutta
    • , James A. Berkley
    • , Robert H. J. Bandsma
    • , Marko Kerac
    • , Indi Trehan
    •  & André Briend
  • Research | | open

    Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.

    • Sumeet Pal Singh
    • , Sharan Janjuha
    • , Theresa Hartmann
    • , Özge Kayisoglu
    • , Judith Konantz
    • , Sarah Birke
    • , Priyanka Murawala
    • , Ezzaldin Ahmed Alfar
    • , Kei Murata
    • , Anne Eugster
    • , Naoki Tsuji
    • , Edward R. Morrissey
    • , Michael Brand
    •  & Nikolay Ninov
  • Reviews |

    Proton-pump inhibitors (PPIs) are widely used for gastric acid suppression in a number of gastric-acid-related diseases, including GERD. However, in recent years, increasing evidence of adverse events has been reported, raising concerns with clinicians and patients. This Review provides an update on the complications and risks of PPI use.

    • Peter Malfertheiner
    • , Arne Kandulski
    •  & Marino Venerito
  • Reviews |

    Patients who are obese and also consume excess alcohol are at increased risk of liver-related disease. In this Review, Parker and colleagues discuss how alcohol and obesity affect adipose tissue function, and describe the importance of the adipose-tissue–liver axis in liver disease pathogenesis and outcomes.

    • Richard Parker
    • , Seung-Jin Kim
    •  & Bin Gao
  • Reviews |

    NAFLD is growing in prevalence worldwide, and has emerged as a leading cause of end-stage liver disease in many countries. In this Review, the authors describe the global epidemiology of NAFLD, discuss associated risk factors and outline challenges for screening and management.

    • Zobair Younossi
    • , Quentin M. Anstee
    • , Milena Marietti
    • , Timothy Hardy
    • , Linda Henry
    • , Mohammed Eslam
    • , Jacob George
    •  & Elisabetta Bugianesi

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