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Signs and symptoms are abnormalities that can indicate a potential medical condition. Whereas a symptom is subjective, that is, apparent only to the patient (for example back pain or fatigue), a sign is any objective evidence of a disease that can be observed by others (for example a skin rash or lump).
Czech et al. develop and clinically validate a sensor-based approach to measure upper and lower body bradykinesia in an early Parkinson’s disease population. Results demonstrate enhanced sensitivity of sensor-based digital measurements to disease progression over one year relative to current clinical measurement standards.
Community screening could be used for the monitoring, early detection and prevention of for depression, and to maximize the effects of the policies to reduce its burden.
The voltage-gated sodium channel Nav1.7 is expressed on chondrocytes, regulates chondrocyte biology and osteoarthritis progression, and is a promising dual target for modifying disease while providing pain relief in osteoarthritis.