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| Open AccessIdentification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening
- Hadley Mouhsine
- , Hélène Guillemain
- & Jean-François Zagury
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| Open AccessDistinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin
- Shoni Bruell
- , Ashish Sethi
- & Ross A. D. Bathgate
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| Open AccessNovel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach
- Kai-Cheng Hsu
- , Chang-Yi Liu
- & Wei-Jan Huang
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| Open AccessDifferences in pharmacodynamic responses to rocuronium in normal or injured orbicularis oris are associated with expression of acetylcholine receptor subunits
- Yong Huang
- , Yian Xing
- & Shitong Li
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| Open AccessImipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking
- Sineewanlaya Wichit
- , Rodolphe Hamel
- & Dorothée Missé
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| Open AccessUsing nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time
- Carl W. White
- , Hannah K. Vanyai
- & Kevin D. G. Pfleger
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| Open AccessAction sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development
- Tobias Palmér
- , Fredrik Ek
- & Per Petersson
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| Open AccessTargeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interaction
- Abigail L. Male
- , Fedor Forafonov
- & Ali Tavassoli
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| Open AccessInhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos
- Ting Li
- , Xiuqiong Fu
- & Zhiling Yu
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| Open AccessMechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats
- Harsh Dweep
- , Yuji Morikawa
- & Weida Tong
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| Open AccessPluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier
- Xin Meng
- , Jiansheng Liu
- & Teng Shen
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| Open AccessML290 is a biased allosteric agonist at the relaxin receptor RXFP1
- Martina Kocan
- , Mohsin Sarwar
- & Roger J. Summers
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| Open AccessCuring the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
- Wei Qi
- , Longlong Tian
- & Wangsuo Wu
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| Open AccessIdentification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain
- Han-Yue Qiu
- , Xiang Zhu
- & Yong-Hua Yang
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| Open AccessAstragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation
- Zhiwei Dong
- , Pei Zhao
- & Tongtong Cao
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| Open AccessPotent anti-cancer effects of less polar Curcumin analogues on gastric adenocarcinoma and esophageal squamous cell carcinoma cells
- Fatemeh Alibeiki
- , Naser Jafari
- & Hadi Peeri Dogaheh
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| Open AccessNovel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2
- Mario Brufani
- , Nicoletta Rizzi
- & Adriana Maggi
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| Open AccessIdentification of a small molecule that primes the type I interferon response to cytosolic DNA
- Samira Khiar
- , Marianne Lucas-Hourani
- & Pierre-Olivier Vidalain
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| Open AccessMonitoring ZEO apoptotic potential in 2D and 3D cell cultures and associated spectroscopic evidence on mode of interaction with DNA
- Fahimeh Salehi
- , Hossein Behboudi
- & Sussan K. Ardestani
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| Open AccessDevelopment of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy
- Yukiya Sako
- , Kensuke Ninomiya
- & Masatoshi Hagiwara
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| Open AccessIdentification of Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides
- Cai Hong Koh
- , Jianjun Wu
- & Heming Wei
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| Open AccessCinnamon induces browning in subcutaneous adipocytes
- Hiu Yee Kwan
- , Jiahui Wu
- & Zhi-ling Yu
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| Open AccessOrganoid-based epithelial to mesenchymal transition (OEMT) model: from an intestinal fibrosis perspective
- Soojung Hahn
- , Myeong-Ok Nam
- & Jongman Yoo
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| Open AccessA Bioactive Chemical Markers Based Strategy for Quality Assessment of Botanical Drugs: Xuesaitong Injection as a Case Study
- Zhenzhong Yang
- , Qing Shao
- & Xiaohui Fan
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| Open AccessHybridizing Feature Selection and Feature Learning Approaches in QSAR Modeling for Drug Discovery
- Ignacio Ponzoni
- , Víctor Sebastián-Pérez
- & Nuria E. Campillo
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| Open AccessCallistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis
- Yu-Qing Xiang
- , Hong-Xin Liu
- & Sheng-Xiang Qiu
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| Open AccessSimvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice
- Hui Wang
- , Jia Zhou
- & Jing Shang
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| Open AccessPreparation, characterization and pharmacokinetics of cyadox nanosuspension
- Adeel Sattar
- , Dongmei Chen
- & Zonghui Yuan
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| Open AccessTreatment effects of the traditional Chinese medicine Shenks in bleomycin-induced lung fibrosis through regulation of TGF-beta/Smad3 signaling and oxidative stress
- Haiyan Chu
- , Ying Shi
- & Jiucun Wang
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| Open AccessIdentification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia
- Mattia Mori
- , Luca Tottone
- & Rocco Palermo
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| Open AccessFK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy
- Enshuang Guo
- , Renlong Li
- & Xiaojing Jiang
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| Open AccessCarcinoPred-EL: Novel models for predicting the carcinogenicity of chemicals using molecular fingerprints and ensemble learning methods
- Li Zhang
- , Haixin Ai
- & Hongsheng Liu
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| Open AccessObestatin controls skeletal muscle fiber-type determination
- Icía Santos-Zas
- , Tania Cid-Díaz
- & Jesus P. Camiña
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| Open AccessA Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis
- Hongfen Yang
- , Yasmeen Abouelhassan
- & Robert W. Huigens
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| Open AccessPhysicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine
- Sophie N. B. Selby-Pham
- , Rosalind B. Miller
- & Louise E. Bennett
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| Open AccessDesign and evaluation of EphrinA1 mutants with cerebral protective effect
- Yuanjun Zhu
- , Yuanqing Gao
- & Yinye Wang
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| Open AccessIntranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
- Myosotys Rodriguez
- , Jessica Lapierre
- & Nazira El-Hage
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| Open AccessStapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics
- Tetsuro Yoshimaru
- , Keisuke Aihara
- & Toyomasa Katagiri
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| Open AccessEnhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery
- D. Thean
- , J. S. Ebo
- & C. J. Brown
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| Open AccessSrc-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis
- Tung-Hung Su
- , Chung-Wai Shiau
- & Jia-Horng Kao
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| Open AccessBiliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo
- Remco van Dijk
- , Sem J. Aronson
- & Piter J. Bosma
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| Open AccessDesign, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer
- Vinod Kumar
- , Amit Kumar Chaudhary
- & Ram I. Mahato
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| Open AccessRare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
- Wenling Wang
- , Tengfei Song
- & Zhizhen Zhang
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| Open AccessHydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib
- Srinivasaraghavan Kannan
- , Mohan R. Pradhan
- & Chandra Verma
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| Open AccessA New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula
- Jinghui Wang
- , Yan Li
- & Yonghua Wang
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| Open AccessLow-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
- Adam S. Hogendorf
- , Agata Hogendorf
- & Andrzej J. Bojarski
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| Open AccessRetro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
- Maria Vincenza Carriero
- , Katia Bifulco
- & Antonello Pessi
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| Open AccessPluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease
- Christopher J. Collins
- , Bradley P. Loren
- & David H. Thompson
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| Open AccessKanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
- Yijia Wang
- , Chunze Zhang
- & Shaobin Hou