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Article |
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites
The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.
- Paula Martinez
- , Maria Thanasoula
- & Maria A. Blasco
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Article |
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Mammalian Rap1 protein is found to have a non-telomeric function in regulating the substrate specificity of IKKs towards the p65 subunit of NF-κB, leading to NF-κB transcriptional activity.
- Hsiangling Teo
- , Sourav Ghosh
- & Vinay Tergaonkar
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Article |
Molecular control of kinetochore-microtubule dynamics and chromosome oscillations
The core kinetochore protein CENP-H is shown to be required for the organization of the metaphase plate. CENP-H regulates microtubule plus-end dynamics, and chromosome oscillations, which are shown to be essential for chromosome congression.
- Ana C. Amaro
- , Catarina P. Samora
- & Patrick Meraldi
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Letter |
The Nup107-160 complex and γ-TuRC regulate microtubule polymerization at kinetochores
The γ-tubulin ring complex (γ-TuRC) nucleates microtubules. The nuclear pore subcomplex Nup107-160 is found to interact and cooperate with γ-TuRC to nucleate microtubules at kinetochores, thereby promoting spindle assembly.
- Ram Kumar Mishra
- , Papia Chakraborty
- & Mary Dasso