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Article
| Open AccessLong-distance electron transfer in a filamentous Gram-positive bacterium
Long-distance extracellular electron transfer has been observed in Gram-negative bacteria. Here, Yang et al. show that a filamentous, unicellular Gram-positive bacterium is capable of bidirectional extracellular electron transfer, and forms centimetre-range conductive networks consisting of 1mm-long cells and conductive appendages.
- Yonggang Yang
- , Zegao Wang
- & Mingdong Dong
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Article
| Open AccessPredicting wavelength-dependent photochemical reactivity and selectivity
Predicting the conversion and selectivity of a photochemical reactions is challenging. Here, the authors introduce a framework for the quantitative prediction of the time-dependent progress of a photoligation reaction and predict LED-light induced conversion through a wavelength-resolved numerical simulation.
- Jan P. Menzel
- , Benjamin B. Noble
- & Christopher Barner-Kowollik
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Article
| Open AccessProgrammable site-selective labeling of oligonucleotides based on carbene catalysis
The methods for investigation of DNA-binding proteins require site-selective chemical modifications to be introduced into oligonucleotides. Here, the authors report a chemo- and regioselective method for the modification of unpaired guanosines in single- and double-stranded oligonucleotides, based on Rh(I)-carbene catalysis.
- Yang-Ha Lee
- , Eunsoo Yu
- & Cheol-Min Park
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Article
| Open AccessQuantitative interpretation explains machine learning models for chemical reaction prediction and uncovers bias
Machine learning algorithms offer new possibilities for automating reaction procedures. The present paper investigates automated reaction’s prediction with Molecular Transformer, the state-of-the-art model for reaction prediction, proposing a new debiased dataset for a realistic assessment of the model’s performance.
- Dávid Péter Kovács
- , William McCorkindale
- & Alpha A. Lee
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Article
| Open AccessRational strain engineering of single-atom ruthenium on nanoporous MoS2 for highly efficient hydrogen evolution
The modulation of single-atom catalyst properties for industrial applications remains challenging. Here, authors use strain engineering to amplify the synergistic effect between MoS2’s sulphur vacancies and single-atom Ru sites and accelerate H2 evolution electrocatalysis.
- Kang Jiang
- , Min Luo
- & Yongwen Tan
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Article
| Open AccessEngineering motile aqueous phase-separated droplets via liposome stabilisation
Bio-mimetic motion has been hard to achieve due to a lack of biocompatible conditions. Here, the authors report the creation of a liposome-stabilised aqueous PEG/dextran Pickering-like emulsion system with motion induced by the Marangoni effect and characterised by negative chemotaxis.
- Shaobin Zhang
- , Claudia Contini
- & Oscar Ces
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Article
| Open AccessModulating electron density of vacancy site by single Au atom for effective CO2 photoreduction
The electron density of reactive sites significantly affects catalytic performances. Here, authors demonstrate the electron density of different reactive sites can be modulated by regulating the type of vacancy and the size of Au, leading to effective CO2 photoreduction.
- Yuehan Cao
- , Lan Guo
- & Ying Zhou
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Article
| Open AccessDirect catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenriched α-chiral BCPs.
- Marie L. J. Wong
- , Alistair J. Sterling
- & Edward A. Anderson
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Article
| Open AccessDual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
Metallaphototoredox catalysis has been rarely applied to reductive cross-couplings, in contrast to typical redox-neutral methods. Here, the authors report a mild Ni/photoredox-catalyzed reductive cross-coupling of aryl iodides and α-chloroboranes, further enriching the metallaphotoredox chemistry.
- Purui Zheng
- , Pan Zhou
- & Tao XU
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Article
| Open AccessPervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
Connecting conformational dynamics and epistasis has so far been limited to a few proteins and a single fitness trait. Here, the authors provide evidence of positive epistasis on multiple catalytic traits in the evolution and dynamics of engineered cytochrome P450 monooxygenase, offering insights for in silico protein design.
- Carlos G. Acevedo-Rocha
- , Aitao Li
- & Manfred T. Reetz
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Article
| Open AccessOn-surface preparation of coordinated lanthanide-transition-metal clusters
The preparation of lanthanide-transition metal clusters containing multiple lanthanide atoms remains challenging. Here, the authors present the controlled on-surface formation of ligand-stabilized heterometallic Ce/Au clusters containing two, three and four Ce atoms bridged by Au adatoms.
- Jing Liu
- , Jie Li
- & Yongfeng Wang
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Article
| Open AccessDouble sulfur vacancies by lithium tuning enhance CO2 electroreduction to n-propanol
Electrochemical CO2 reduction to the valuable n-propanol is challenging due to the complicated C3 forming mechanism. Here, authors demonstrate double sulfur vacancies formed on hexagonal copper sulfide can serve as efficient electrocatalytic centers.
- Chen Peng
- , Gan Luo
- & Gengfeng Zheng
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Article
| Open AccessA source of isotopically light organic carbon in a low-pH anoxic marine zone
Anoxic marine zones are expanding and intensifying with climate change. Here the authors show that microbial dark carbon fixation influences the carbonate system and the stable isotope composition in waters off Chile, contributing up to 35% of the organic carbon reaching the mesopelagic region.
- Cristian A. Vargas
- , Sebastian I. Cantarero
- & Joe Salisbury
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Article
| Open AccessMetabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
Studies of metabolites in neurodegeneration have not yet used sebum as a source fluid. Here the authors demonstrate the potential of metabolomics of sebum samples from individuals with Parkinson’s disease and controls.
- Eleanor Sinclair
- , Drupad K. Trivedi
- & Perdita Barran
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Article
| Open AccessStereoselectivity in spontaneous assembly of rolled incommensurate carbon bilayers
Incommensurate pairing is a type of stereoisomerism, observed in carbon bilayers, that arises from the twisted orientations of the graphitic layers. Here, the authors create a finite molecular version of an incommensurate carbon bilayer in the form of two concentrically assembled cylindrical molecules.
- Taisuke Matsuno
- , Yutaro Ohtomo
- & Hiroyuki Isobe
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Article
| Open AccessDevelopment of a mugineic acid family phytosiderophore analog as an iron fertilizer
Iron is an essential plant nutrient that is poorly bioavailable in alkaline soils, resulting in reduced agricultural productivity. Here, the authors report the synthesis of stable and cheap iron-chelator, proline-2’-deoxymugineic acid (PDMA), and demonstrate its utility as potential fertilizer.
- Motofumi Suzuki
- , Atsumi Urabe
- & Kosuke Namba
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Article
| Open AccessEvolution and universality of two-stage Kondo effect in single manganese phthalocyanine molecule transistors
The Kondo effect can serve as a powerful paradigm to understand strongly correlated many-body processes in physics. Here, Guo et al. utilize single molecule transistor devices as a testbed to study multi-level Kondo correlation and show electrical gate evolution and the universality of the two-stage Kondo effect.
- Xiao Guo
- , Qiuhao Zhu
- & Wenjie Liang
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Article
| Open AccessNear quantitative synthesis of urea macrocycles enabled by bulky N-substituent
Macrocycles are molecular structures extensively used in the design of catalysts, therapeutics and supramolecular assemblies but synthesis procedures that can produce macrocycles in high yield under high reaction concentrations are rare. Here the authors report the use of dynamic hindered urea bond for the construction of urea macrocycles with high efficiency.
- Yingfeng Yang
- , Hanze Ying
- & Jianjun Cheng
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Article
| Open AccessDirecting reaction pathways via in situ control of active site geometries in PdAu single-atom alloy catalysts
Single-atom alloys are promising catalysts for a number of different reactions. Here, the authors demonstrate that carbon monoxide can be used to transition a PdAu catalyst between a single atom and a cluster phase which exhibit distinct selectivities for ethanol dehydrogenation.
- Mengyao Ouyang
- , Konstantinos G. Papanikolaou
- & E. Charles H. Sykes
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Article
| Open AccessShallow distance-dependent triplet energy migration mediated by endothermic charge-transfer
Spin-triplet energy transfer in molecular systems underlies important applications for chemistry and devices. Here, the authors investigate the triplet energy transfer in CdSe quantum dots with varying ZnS shell thicknesses to surface-anchored anthracene molecules and identify a stepwise mechanism mediated by endothermic charge-transfer states.
- Runchen Lai
- , Yangyi Liu
- & Kaifeng Wu
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Article
| Open AccessStructural resolution of switchable states of a de novo peptide assembly
So far most of the de novo designed proteins are for single states only. Here, the authors present the de novo design and crystal structure determination of a coiled-coil peptide that assembles into multiple, distinct conformational states under the same conditions and further characterise its properties with biophysical experiments, NMR and MD simulations.
- William M. Dawson
- , Eric J. M. Lang
- & Derek N. Woolfson
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Article
| Open AccessPressure-induced ferroelectric-like transition creates a polar metal in defect antiperovskites Hg3Te2X2 (X = Cl, Br)
Generally, ferroelectricity in ABO3 perovskites is suppressed by hydrostatic compression, but the evidence for pressure-induced ferroelectricity remains elusive. Here, the authors find a direct ferroelectric-like structural transition induced by pressure in defect antiperovskites.
- Weizhao Cai
- , Jiangang He
- & Shanti Deemyad
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Article
| Open AccessPredicting orientation-dependent plastic susceptibility from static structure in amorphous solids via deep learning
Predicting a priori local defects in amorphous materials remains a grand challenge. Here authors combine a rotationally non-invariant structure representation with deep-learning to predict the propensity for shear transformations of amorphous solids for different loading orientations, only given the static structure.
- Zhao Fan
- & Evan Ma
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Article
| Open AccessSpecific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine.
- Annika Meiners
- , Sandra Bäcker
- & Shirley K. Knauer
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Article
| Open AccessSelective E to Z isomerization of 1,3-Dienes Enabled by A Dinuclear Mechanism
Geometric E to Z double C=C bond isomerization is challenging as it requires kinetic trapping of the Z-isomer with injection of chemical energy. Here, the authors report a dinuclear Pd(I)−Pd(I) complex that mediates selective isomerization of E-1,3-dienes to the Z-isomers without photoirradiation.
- Eiji Kudo
- , Kota Sasaki
- & Tetsuro Murahashi
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Article
| Open AccessKinesin-1 activity recorded in living cells with a precipitating dye
Monitoring the activity of the processive motor protein kinesin-1 in live cells is currently difficult. Here the authors report the fluorogenic small molecule QPD-OTf, a kinesin-1 substrate that causes activity-dependent dye precipitation.
- Simona Angerani
- , Eric Lindberg
- & Nicolas Winssinger
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Article
| Open AccessEnzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides
Rubromycin family of natural products belongs to aromatic polyketides with diverse bioactivities, but details of their biosynthesis are limited. Here, the authors report the complete in vitro reconstitution of enzymatic formation of the spiroketal moiety of rubromycin polyketides, driven by flavin-dependent enzymes, and characterize reaction intermediates.
- Britta Frensch
- , Thorsten Lechtenberg
- & Robin Teufel
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Article
| Open AccessOperando high-pressure investigation of size-controlled CuZn catalysts for the methanol synthesis reaction
The nature of the active species over Cu/ZnO catalysts for methanol synthesis remains elusive. Here, the authors shed light on the evolution of the nanoparticle/support interface and correlate its structural and chemical transformations with changes in the catalytic performance.
- Núria J. Divins
- , David Kordus
- & Beatriz Roldan Cuenya
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Article
| Open AccessIsolated copper–tin atomic interfaces tuning electrocatalytic CO2 conversion
The understanding of catalytic reactions at the atomic interface is vital; however, the characterization and mechanism studies of atomically dispersed catalysts remain challenging. Here, the authors demonstrate Cu–Sn surface alloys with isolated Sn atoms on a Cu host to achieve efficient CO2 to CO conversion.
- Wenhao Ren
- , Xin Tan
- & Chuan Zhao
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Article
| Open AccessDecoupling the origins of irreversible coulombic efficiency in anode-free lithium metal batteries
Anode-free lithium metal battery is one of the most promising candidates for next-generation high energy density battery but suffer from poor cycle life. Here the authors present an integrated protocol to dissect and quantify the irreversible coulombic efficiencies for better understanding of the battery.
- Chen-Jui Huang
- , Balamurugan Thirumalraj
- & Bing Joe Hwang
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Article
| Open AccessUltrastable liquid crystalline blue phase from molecular synergistic self-assembly
Blue phases are spatially ordered yet fragile liquid crystalline structures, bearing applications in optoelectronics and photonics. Hu et al. show that self-assembly within a mixture of different mesogens may significantly broaden the temperature range over which they are stable.
- Wei Hu
- , Ling Wang
- & Huai Yang
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Article
| Open AccessIn situ identification of the metallic state of Ag nanoclusters in oxidative dispersion
Designing ultra small metal nanoclusters or single atoms with metallic state is a challenge. Here, the authors demonstrate the stabilization of ultra small silver clusters in the nearly-metallic state by oxygen adsorption at high temperature, using in situ spectroscopy and microscope technologies.
- Rongtan Li
- , Xiaoyan Xu
- & Xinhe Bao
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Article
| Open AccessMomentarily trapped exciton polaron in two-dimensional lead halide perovskites
Two-dimensional perovskite shows potential for optoelectronic applications due to its large exciton binding energy, yet the exciton-phonon interaction with the polar soft lattice is not well-understood. Here, the authors reveal the intermediate coupling regime where exciton polarons are momentarily trapped by lattice vibrations.
- Weijian Tao
- , Chi Zhang
- & Haiming Zhu
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Article
| Open AccessEvolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria
Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of diversification, and guiding the discovery of polyketides.
- Eric J. N. Helfrich
- , Reiko Ueoka
- & Marnix H. Medema
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Article
| Open AccessImine as a linchpin approach for meta-C–H functionalization
Site-selective C–H functionalization still faces some challenges, such as the introduction and removal of an appropriate directing group. Here, the authors introduce a temporary directing group for selective meta-C–H functionalization of 2-arylbenzaldehydes via reversible imine formation.
- Sukdev Bag
- , Sadhan Jana
- & Debabrata Maiti
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Article
| Open AccessGraphene/MoS2/FeCoNi(OH)x and Graphene/MoS2/FeCoNiPx multilayer-stacked vertical nanosheets on carbon fibers for highly efficient overall water splitting
While water-splitting electrocatalysis offers a renewable means for carbon-neutral energy production, it is a challenge to design efficient, active, and stable catalysts. Here, authors prepare multilayer composite nanosheet materials as bifunctional water-splitting electrocatalysts.
- Xixi Ji
- , Yanhong Lin
- & Jie Yu
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Article
| Open AccessGeneral molten-salt route to three-dimensional porous transition metal nitrides as sensitive and stable Raman substrates
Fabrication of transition metal nitrides generally requires harsh conditions due to the high activation energy barrier for nucleation. Here, the authors report a mild molten-salt route for the synthesis of three-dimensional porous metal nitrides, VN, MoN, WN, and TiN.
- Haomin Guan
- , Wentao Li
- & Guangcheng Xi
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Article
| Open AccessThermochromic aggregation-induced dual phosphorescence via temperature-dependent sp3-linked donor-acceptor electronic coupling
Aggregation-induced emission (AIE) has proven to be a viable strategy to achieve highly efficient room temperature phosphorescence (RTP) in bulk by restricting molecular motions. Here, the authors present an RTP design strategy by combining the concept of AIE and donor-acceptor motif and demonstrate unusual thermochromic dual phosphorescence.
- Tao Wang
- , Zhubin Hu
- & Guoqing Zhang
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Article
| Open AccessPhotoresponsive supramolecular coordination polyelectrolyte as smart anticounterfeiting inks
Photoluminescence printing is a widely applied anticounterfeiting technique but there are still challenges in developing new generation anticounterfeiting materials providing a high security level. Here, the authors demonstrate coordination dependent photochromic luminescence in a supramolecular coordination polyelectrolyte for multiple information authentication.
- Zhiqiang Li
- , Xiao Liu
- & Yanli Zhao
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Article
| Open AccessRational design of isostructural 2D porphyrin-based covalent organic frameworks for tunable photocatalytic hydrogen evolution
Covalent organic frameworks (COFs) present well-defined materials for constructing structure-property-activity relationships. Herein, authors explore isostructural porphyrinic two-dimensional COFs with tunable of photocatalytic H2 production rates arising from tailored charge-carrier dynamics.
- Rufan Chen
- , Yang Wang
- & Cheng Wang
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Article
| Open AccessModulating electronic structure of metal-organic frameworks by introducing atomically dispersed Ru for efficient hydrogen evolution
Developing high-performance, neutral-media H2-evolution electrocatalysts is important for clean and sustainable hydrogen energy, yet rare, expensive elements are most active. Here, authors show that metal-organic frameworks modified with single ruthenium atoms as high-performances catalysts.
- Yamei Sun
- , Ziqian Xue
- & Cheng-Yong Su
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Article
| Open AccessCatalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines
Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives.
- Jia-Wang Wang
- , Yan Li
- & Yao Fu
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Article
| Open AccessElectrical switching of high-performance bioinspired nanocellulose nanocomposites
Switching mechanical properties in stiff bioinspired nanocomposites is challenging as they contain high fractions of hard reinforcements. Here, the authors demonstrate reversible electrical switching in highly-reinforced cellulose nanopapers using an applied low direct current.
- Dejin Jiao
- , Francisco Lossada
- & Andreas Walther
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Article
| Open AccessA tris-spiro metalla-aromatic system featuring Craig-Möbius aromaticity
Spiroaromatic compounds are advantageous platforms for designing expanded aromatic systems. Herein, the authors present a tris‐spiro metalla‐aromatic Vanadium compound which forms a 40π Craig‐Möbius aromatic system.
- Zhe Huang
- , Yongliang Zhang
- & Zhenfeng Xi
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Article
| Open AccessMarine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp3)-H olefination mediated by donor/donor carbenes
Furanocembranoid-like natural products with the alkene-substituted furan scaffold display a range of biological activities, but are difficult to access. Here, the authors report a modular biomimetic strategy to synthesise diverse alkene-substituted furan-containing macrolactams via palladium-catalysed unactivated Csp3-H olefination.
- Jiping Hao
- , Xueying Guo
- & Weibo Yang
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Article
| Open AccessA family of ionic supersalts with covalent-like directionality and unconventional multiferroicity
Binary ionic crystals, such as NaCl, are non-polar due to directionless ionic bonding interactions. Here, the authors show that polarity can be developed by using superalkali/superhalogen ions as building blocks, leading to ionic supersalts with ferroelectricity, ferroelasticity or even triferroicity.
- Yaxin Gao
- , Menghao Wu
- & Puru Jena
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Article
| Open AccessNanoengineered chiral Pt-Ir alloys for high-performance enantioselective electrosynthesis
Tremendous efforts have been made over the past decades regarding the development of materials with enantioselective properties. Here, the authors present a nanostructured chiral imprinted metal alloy that exhibits high enantioselectivity and stability for the electrosynthesis of chiral molecules.
- Sopon Butcha
- , Sunpet Assavapanumat
- & Alexander Kuhn
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Article
| Open AccessThe atomistic details of the ice recrystallisation inhibition activity of PVA
Understanding ice re-crystallization is key to improve the current cryopreservation technologies. Here, the authors bring together experiments and simulations to unravel the atomistic details of the ice re-crystallization inhibition (IRI) activity of poly(vinyl)alcohol—the most potent biomimetic IRI agent.
- Fabienne Bachtiger
- , Thomas R. Congdon
- & Gabriele C. Sosso
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Article
| Open AccessMechanically robust amino acid crystals as fiber-optic transducers and wide bandpass filters for optical communication in the near-infrared
Fiber-optics based on organic crystals could have potential for unique telecommunications applications but typically transmit visible wavelengths. Here the authors present mechanically robust organic crystals with favourable optical properties across the main telecommunication bands in the near-infrared.
- Durga Prasad Karothu
- , Ghada Dushaq
- & Panče Naumov
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