Cell division articles within Nature

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  • Letter |

    The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.

    • Ulrich Elling
    • , Reiner A. Wimmer
    •  & Josef M. Penninger

  • Letter |

    Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.

    • Hee Won Yang
    • , Mingyu Chung
    •  & Tobias Meyer

  • Letter |

    Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

    • Shom Goel
    • , Molly J. DeCristo
    •  & Jean J. Zhao

  • Letter |

    The stretch-activated channel Piezo1 controls homeostatic epithelial cell numbers by activating cells to divide rapidly when under stretch strain from low density, and by activating cells to extrude and die when cells are under crowding strain.

    • S. A. Gudipaty
    • , J. Lindblom
    •  & J. Rosenblatt

  • Letter |

    The near-complete in vitro reconstitution of the mitotic spindle assembly checkpoint reveals how the assembly of its effector, the mitotic checkpoint complex, is catalysed.

    • Alex C. Faesen
    • , Maria Thanasoula
    •  & Andrea Musacchio

  • Article |

    A high-resolution structure of a complex between the anaphase-promoting complex (APC/C) and the mitotic checkpoint complex (MCC) reveals how MCC interacts with and represses APC/C by obstructing substrate recognition and suppressing E3 ligase activity.

    • Claudio Alfieri
    • , Leifu Chang
    •  & David Barford

  • Letter |

    During cell division, chromosomes are maintained as individual units; this process is shown to be mediated by the cell proliferation marker Ki-67, which has biophysical properties similar to those of surfactants.

    • Sara Cuylen
    • , Claudia Blaukopf
    •  & Daniel W. Gerlich

  • Letter |

    The crystal structures of the protease domain of separase are reported, showing how separase recognizes cohesin, and how phosphorylation of the cleavage site enhances separase activity.

    • Zhonghui Lin
    • , Xuelian Luo
    •  & Hongtao Yu

  • Letter |

    Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.

    • Sheroy Minocherhomji
    • , Songmin Ying
    •  & Ian D. Hickson

  • Letter |

    Fate-mapping hypoxic cells in the mouse heart identifies a rare population of cycling cardiomyocytes, which show characteristics of neonatal cardiomyocytes, including smaller size and mononucleation, and contribute to new cardiomyocyte formation in the adult heart.

    • Wataru Kimura
    • , Feng Xiao
    •  & Hesham A. Sadek

  • Letter |

    The ESCRT-III complex is implicated in the reformation of the nuclear envelope; the CHMP2A component of ESCRT-III is directed to the forming nuclear envelope through classical ESCRT-assembly mechanisms, with the help of the p97 complex component UFD1, and provides an activity essential for nuclear envelope reformation.

    • Yolanda Olmos
    • , Lorna Hodgson
    •  & Jeremy G. Carlton

  • Article |

    The mechanism for chromothripsis, “shattered” chromosomes that can be observed in cancer cells, is unknown; here, using live-cell imaging and single-cell sequencing, chromothripsis is shown to occur after a chromosome is isolated into a micronucleus, an abnormal nuclear structure.

    • Cheng-Zhong Zhang
    • , Alexander Spektor
    •  & David Pellman

  • Article |

    This study identifies a crucial role for fatty acid oxidation (FAO) in endothelial cells during angiogenesis, and reveals that fatty-acid-derived carbons are used for the de novo synthesis of nucleotides, and hence FAO stimulates vessel sprouting by increasing endothelial cell proliferation.

    • Sandra Schoors
    • , Ulrike Bruning
    •  & Peter Carmeliet

  • Letter |

    Meiotic recombination is initiated by a fairly uniform distribution of hundreds of DNA double-strand breaks catalysed by the Spo11 protein; here, Tel1 (orthologue of human ATM) is shown to be required for the localized inhibition that prevents double-strand breaks from forming close to one another.

    • Valerie Garcia
    • , Stephen Gray
    •  & Matthew J. Neale

  • Article |

    The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.

    • Jihye Kim
    • , Kei-ichiro Ishiguro
    •  & Yoshinori Watanabe

  • Letter |

    The activation and coordination of phosphatase activity is important during mitotic exit; here, a mitotic phosphatase relay is described in fission yeast between the two major phosphatases, PP1 and PP2A, a mode of regulation that may be a feature of signalling networks across eukaryotes.

    • Agnes Grallert
    • , Elvan Boke
    •  & Iain M. Hagan

  • Letter |

    A new mechanism is identified for correct placement of the division machinery in Streptococcus pneumoniae that relies on the novel factor MapZ to form ring structures at the cell equator; these structures move apart as the cell elongates, acting as permanent markers of division sites.

    • Aurore Fleurie
    • , Christian Lesterlin
    •  & Christophe Grangeasse

  • Letter |

    By binding and inhibiting a second CDC20 molecule, the mitotic checkpoint complex can convert a local ‘wait’ signal from unattached kinetochores to inhibit the anaphase promoting complex/cyclosome throughout the cell and avoid premature cell division.

    • Daisuke Izawa
    •  & Jonathon Pines

  • Article |

    The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins; here the complete secondary structure architecture of human APC/C complexed with its coactivator CDH1 and substrate HSL1 is determined at 7.4 Å resolution, revealing allosteric changes induced by the coactivator that enhance affinity for UBCH10–ubiqutin.

    • Leifu Chang
    • , Ziguo Zhang
    •  & David Barford

  • Article |

    DNA double-stranded breaks (DSBs) are shown to form in greater numbers in yeast cells lacking ZMM proteins, which are traditionally regarded as acting strictly downstream of DSB formation; these findings shed light on how cells balance the beneficial and deleterious outcomes of DSB formation.

    • Drew Thacker
    • , Neeman Mohibullah
    •  & Scott Keeney

  • Letter |

    The Drosophila tumour suppressors Scribbled and Discs large 1 are found to be essential regulators of planar spindle alignment during epithelial cell division; aberrant effects of spindle alignment are shown to be corrected through apoptosis, and the suppression of this mechanism can result in epithelial dysplasia and tumorigenesis.

    • Yu-ichiro Nakajima
    • , Emily J. Meyer
    •  & Matthew C. Gibson

  • Letter |

    Folate receptor-α (FRα) is overexpressed in many cancer cells and is therefore an important therapeutic target: here the X-ray crystal structure of folate-bound FRα is presented, revealing details of the ligand-binding pocket that may be useful in the development of small-molecule inhibitors for anticancer therapy.

    • Chen Chen
    • , Jiyuan Ke
    •  & Karsten Melcher

  • Letter |

    Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M arrest.

    • Emily C. Dykhuizen
    • , Diana C. Hargreaves
    •  & Gerald R. Crabtree

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