Mitosis articles within Nature

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  • Article
    | Open Access

    Following skin injury, wild-type epithelial cells outcompete oncogenic Ras G12V mutant cells owing to differential activation of the EGFR signalling pathway during injury repair.

    • Sara Gallini
    • , Karl Annusver
    •  & Valentina Greco

  • Article
    | Open Access

    Histone deacetylation at the onset of mitosis induces a chromatin-intrinsic phase transition that endows chromosomes with the physical characteristics necessary for their precise movement during cell division.

    • Maximilian W. G. Schneider
    • , Bryan A. Gibson
    •  & Daniel W. Gerlich

  • Article
    | Open Access

    The core cell cycle is largely driven by increasing total CDK activity together with minor differences in the substrate specificity of the CDKs initiating DNA replication and mitosis.

    • Souradeep Basu
    • , Jessica Greenwood
    •  & Paul Nurse

  • Article |

    The surfactant-like protein Ki-67 mediates the clustering of chromosomes during mitotic exit, which displaces large cytoplasmic molecules from the future nuclear space and thus enables the separation of cytoplasmic and nuclear components before the nuclear envelope reforms.

    • Sara Cuylen-Haering
    • , Mina Petrovic
    •  & Daniel W. Gerlich

  • Article |

    In a study performed in Schizosaccharomyces pombe, ‘closed mitosis’ is shown to occur via local disassembly of the nuclear envelope within the narrow bridge connecting segregating daughter nuclei, and a key role is identified for Les1, which restricts nuclear envelope breakdown to the bridge.

    • Gautam Dey
    • , Siân Culley
    •  & Buzz Baum

  • Article |

    The cryo-EM structure of the γ-tubulin ring complex (γ-TuRC) from Xenopus laevis provides insights into the molecular organization of the complex, and shows that actin is a structural component that is functionally relevant to microtubule nucleation.

    • Peng Liu
    • , Erik Zupa
    •  & Elmar Schiebel

  • Letter |

    The stretch-activated channel Piezo1 controls homeostatic epithelial cell numbers by activating cells to divide rapidly when under stretch strain from low density, and by activating cells to extrude and die when cells are under crowding strain.

    • S. A. Gudipaty
    • , J. Lindblom
    •  & J. Rosenblatt

  • Letter |

    The ESCRT-III complex is implicated in the reformation of the nuclear envelope; the CHMP2A component of ESCRT-III is directed to the forming nuclear envelope through classical ESCRT-assembly mechanisms, with the help of the p97 complex component UFD1, and provides an activity essential for nuclear envelope reformation.

    • Yolanda Olmos
    • , Lorna Hodgson
    •  & Jeremy G. Carlton

  • Letter |

    By binding and inhibiting a second CDC20 molecule, the mitotic checkpoint complex can convert a local ‘wait’ signal from unattached kinetochores to inhibit the anaphase promoting complex/cyclosome throughout the cell and avoid premature cell division.

    • Daisuke Izawa
    •  & Jonathon Pines

  • Article |

    The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins; here the complete secondary structure architecture of human APC/C complexed with its coactivator CDH1 and substrate HSL1 is determined at 7.4 Å resolution, revealing allosteric changes induced by the coactivator that enhance affinity for UBCH10–ubiqutin.

    • Leifu Chang
    • , Ziguo Zhang
    •  & David Barford

  • Letter |

    The current model to explain accurate chromosome segregation after DNA replication holds that kinetochore–microtubule attachments exert tension across the centromere and are stabilized by spatial separation from inner centromere-localized Aurora B; here an alternative model is presented, wherein active Aurora B produced by clustering is sufficient to ensure biorientation through a mechanism that is intrinsic to the kinetochore.

    • Christopher S. Campbell
    •  & Arshad Desai

  • Article |

    The crystal structure of fission yeast mitotic checkpoint complex (MCC) reveals how MCC assembly is regulated and the molecular basis of anaphase-promoting complex (APC/C) inhibition by MCC.

    • William C. H. Chao
    • , Kiran Kulkarni
    •  & David Barford

  • Article |

    This study focuses on developing mouse skin where mitotic basal progenitor cells switch from symmetric divisions to asymmetric division concomitant with stratification. Using a novel technical approach, the genetic pathway regulating spindle orientation is dissected, providing the first direct evidence that the proteins governing spindle orientation (LGN, NuMA and Dctn1) promote asymmetric cell divisions regulated by Notch signalling in mammalian cells in vivo.

    • Scott E. Williams
    • , Slobodan Beronja
    •  & Elaine Fuchs

  • Article |

    The APC/C is a large multiprotein complex that functions as an E3 ubiquitin ligase to regulate the cell cycle. Here, the entire APC/C complex is reconstituted, and in combination with structural studies a pseudo-atomic model for 70% of the complex is provided. These results contribute towards a molecular understanding of the roles of individual subunits in APC/C assembly and their interactions with co-activators, substrates and regulatory proteins.

    • Anne Schreiber
    • , Florian Stengel
    •  & David Barford

  • Article |

    To investigate the core engine of the eukaryotic mitotic cycle, a minimal control network has been generated in fission yeast that efficiently sustains cellular reproduction. Orderly progression through the major events of the cell cycle is driven by oscillation of an engineered minimal CDK module lacking much of the canonical regulation.

    • Damien Coudreuse
    •  & Paul Nurse

  • News & Views |

    Accurate cell division depends on proper attachment of chromosomes to the microtubule-based division apparatus. An impressive in vitro study shows how applied force plays a pivotal part in regulating such attachment. See Letter p.576

    • Yuta Shimamoto
    •  & Tarun M. Kapoor

  • Letter |

    These authors show that the JmjC domain-containing protein PHF8 has histone demethylase activity against H4K20me1 and is linked to two distinct events during cell cycle progression. PHF8 is recruited to the promoters of genes involved in the G1–S phase transition, where it removes H4K20me1 and contributes to gene activation, whereas dissociation of PHF8 from chromatin in prophase allows H4K20me1 to accumulate during mitosis.

    • Wen Liu
    • , Bogdan Tanasa
    •  & Michael G. Rosenfeld

  • Letter |

    Cyclin F is the founding member of the F-box protein family but its functions are unknown; unlike most cyclins, it does not bind or activate cyclin-dependent kinases. Here the authors identify CP110, a protein essential for centrosome duplication, as a substrate of Cyclin F. CP110 and Cyclin F associate on centrioles during the cell cycle, and Cyclin F is proposed to limit centrosome duplication by targeting CP110 for degradation.

    • Vincenzo D’Angiolella
    • , Valerio Donato
    •  & Michele Pagano

  • News & Views |

    An exceptionally large-scale project aimed at assigning function to all protein-coding genes in the human genome is reported on page 721 by Neumann et al.1. Here are two complementary views on the experimental design and analysis, and on how useful the findings will be to cell biologists.

    • Jason R. Swedlow
    • , Cecilia Cotta-Ramusino
    •  & Stephen J. Elledge

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