Cohesion articles within Nature

Featured

• Article | 29 April 2020

  Convergent genes shape budding yeast pericentromeres

  The three-dimensional structure of pericentromeres in budding yeast is defined by convergent genes, which mark pericentromere borders and trap cohesin complexes loaded at centromeres, generating an architecture that allows correct chromosome segregation.

  • Flora Paldi
  • , Bonnie Alver
  •  & Adele L. Marston

• Article | 08 April 2020

  Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2

  Shugoshin and MAD2 regulate separase-mediated chromosome separation during mitosis, in parallel to a previously identified mechanism involving the anaphase inhibitor securin.

  • Susanne Hellmuth
  • , Laura Gómez-H
  •  & Olaf Stemmann

• Article | 24 December 2014

  Meikin is a conserved regulator of meiosis-I-specific kinetochore function

  The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.

  • Jihye Kim
  • , Kei-ichiro Ishiguro
  •  & Yoshinori Watanabe

• Letter | 12 August 2012

  HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

  The deacetylase enzyme HDAC8 is identified as a crucial regulator of cohesin in humans, and loss-of-function mutations in the HDAC8 gene are found in patients with Cornelia de Lange syndrome.

  • Matthew A. Deardorff
  • , Masashige Bando
  •  & Katsuhiko Shirahige