News & Views |
Featured
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Research Highlights |
Our choice from the recent literature
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Letter |
Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy
Nanoparticles can be utilized to capture tumour antigens and improve their presentation, which in turn improves the efficacy of cancer immunotherapy.
- Yuanzeng Min
- , Kyle C. Roche
- & Andrew Z. Wang
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Article |
Sulfated glycopeptide nanostructures for multipotent protein activation
Highly bioactive supramolecular nanostructures displaying sulfated glycopeptides on their surfaces were designed in order to mimic the polysaccharides that bind and activate a plethora of proteins in mammalian biology during development and tissue regeneration.
- Sungsoo S. Lee
- , Timmy Fyrner
- & Samuel I. Stupp
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Research Highlights |
Our choice from the recent literature
- Alberto Moscatelli
- , Giacomo Prando
- & Wenjie Sun
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Letter |
Amyloid fibril systems reduce, stabilize and deliver bioavailable nanosized iron
Amyloid fibrils from food-grade proteins deliver nanostructured bioavailable iron without cytotoxicity or pathological side effects.
- Yi Shen
- , Lidija Posavec
- & Raffaele Mezzenga
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Article |
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
The transitional link from robust clearance of intravenously injected nanoparticles by strategically placed macrophages in systemic circulation to adverse haemodynamic reactions can be overcome by changing nanoparticle geometry or by prior nanoparticle attachment to erythrocytes
- Peter Popp Wibroe
- , Aaron C. Anselmo
- & Seyed Moein Moghimi
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News & Views |
Evolution of the nanoparticle corona
Understanding how complement proteins bind to nanoparticles and participate in their surface 'corona' can provide further insight into the relevance of the protein corona concept in medicine.
- Marilena Hadjidemetriou
- & Kostas Kostarelos
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Research Highlights |
Our choice from the recent literature
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Article |
Directed assembly of bio-inspired hierarchical materials with controlled nanofibrillar architectures
A combination of mechanical constraints and directed assembly of silk-fibroin leads to the generation of engineered hierarchical structures with control over multiple length scales from the macro, to the micro and nanoscales.
- Peter Tseng
- , Bradley Napier
- & Fiorenzo G. Omenetto
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Article |
Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy
Magnesium silicide nanoparticles can scavenge oxygen in the acidic tumour microenvironment and starve tumours by blocking oxygen and nutrient supply, offering a new avenue for cancer-starvation therapy.
- Chen Zhang
- , Dalong Ni
- & Jianlin Shi
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Article |
Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Immune proteins bind to protein corona on core-shell nanoparticles and undergo dynamic exchange in vivo.
- Fangfang Chen
- , Guankui Wang
- & Dmitri Simberg
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Correspondence |
Kinesin-1 motors can increase the lifetime of taxol-stabilized microtubules
- Cordula Reuther
- , Alejandra Laguillo Diego
- & Stefan Diez
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Correspondence |
Measuring conductivity of living Geobacter sulfurreducens biofilms
- Matthew D. Yates
- , Sarah M. Strycharz-Glaven
- & Leonard M. Tender
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Letter |
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection
6’-Sialyllactose conjugated to polyamidoamine dendrimers at a well-defined valency and spacing can circumvent drug resistance and inhibit influenza A viruses.
- Seok-Joon Kwon
- , Dong Hee Na
- & Robert J. Linhardt
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Letter |
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions
Magnetotactic bacteria that respond to oxygen gradients can be used to carry drug payloads deep into the hypoxic regions of tumours, offering a way to improve the therapeutic index of various nanocarriers.
- Ouajdi Felfoul
- , Mahmood Mohammadi
- & Sylvain Martel
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Article |
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles
Synthetic nanoparticles containing rapamycin — a common immunosuppressant drug — when co-administered with any free antigen can induce immune tolerance, offering a way to rescue novel drugs that have failed in the clinic due to antidrug antibodies.
- Takashi K. Kishimoto
- , Joseph D. Ferrari
- & Roberto A. Maldonado
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Article |
A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy
A magnetic resonance imaging contrast agent that amplifies its signal in response to pH is used to rapidly identify tumours, report hypoxic regions in the tumour and detect millimetre-sized metastatic tumours in the liver of animals.
- Peng Mi
- , Daisuke Kokuryo
- & Kazunori Kataoka
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Article |
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Gold-doped graphene combined with a serpentine-shaped bilayer of gold mesh and polymeric microneedles form a wearable patch for sweat-based diabetes monitoring and feedback therapy.
- Hyunjae Lee
- , Tae Kyu Choi
- & Dae-Hyeong Kim
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Commentary |
Long-term monitoring for nanomedicine implants and drugs
Increasing globalization means that traditional occupational epidemiological approaches may no longer apply, suggesting a need for an alternative model to assess the long-term impact of nanomaterial exposure on health.
- Michaela Kendall
- & Iseult Lynch
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Letter |
Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery
The enhanced extravasation of nanoparticles from tumour blood vessels into the tumour interstitial space has been found to be due to dynamic vents that form transient openings and closings at leaky blood vessels, offering new insights on drug permeability and distribution patterns in tumours.
- Yu Matsumoto
- , Joseph W. Nichols
- & Kazunori Kataoka
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Research Highlights |
Our choice from the recent literature
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Letter |
Durable protein lattices of clathrin that can be functionalized with nanoparticles and active biomolecules
Clathrin, a three-legged protein complex, can form regular two-dimensional lattices on a variety of substrates. These lattices can be functionalized with nanoparticles or enzymes for sensing applications.
- P. N. Dannhauser
- , M. Platen
- & I. A. T. Schaap
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Letter |
In vivo integrity of polymer-coated gold nanoparticles
The polymeric shell surrounding gold nanoparticles may degrade when injected into rats, suggesting that even highly stable colloidal nanoparticles are susceptible to physicochemical changes in vivo.
- Wolfgang G. Kreyling
- , Abuelmagd M. Abdelmonem
- & Wolfgang J. Parak
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Research Highlights |
Our choice from the recent literature
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Article |
Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers
Cerenkov radiation from radionuclides is used to activate titanium dioxide nanophotosensitizers to achieve depth-independent phototherapy.
- Nalinikanth Kotagiri
- , Gail P. Sudlow
- & Samuel Achilefu
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Article |
Strong underwater adhesives made by self-assembling multi-protein nanofibres
Strong underwater adhesive fibres are self-assembled by fusing mussel foot proteins with an amyloid-based protein.
- Chao Zhong
- , Thomas Gurry
- & Timothy K. Lu
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Article |
Biocomputing based on particle disassembly
Particle-based structures can be used to implement a functionally complete set of Boolean logic gates (YES, NOT, AND and OR), and can be made to bind to a target as a result of a computation.
- Maxim P. Nikitin
- , Victoria O. Shipunova
- & Petr I. Nikitin
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Article |
Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines
Nanoparticles with high near-infrared absorption that transit the gut without being absorbed can be used for gastrointestinal imaging using photoacoustic and positron emission tomography.
- Yumiao Zhang
- , Mansik Jeon
- & Jonathan F. Lovell
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News & Views |
Going green with silk
Silk fibroin can be used as a photoresist in water-based electron-beam lithographic processing.
- Alex Robinson
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Letter |
All-water-based electron-beam lithography using silk as a resist
Silk can be used as a negative or positive biofunctional resist in an all-water electron-beam lithography process.
- Sunghwan Kim
- , Benedetto Marelli
- & Fiorenzo G. Omenetto
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Letter |
Bacillus spores as building blocks for stimuli-responsive materials and nanogenerators
Bacillus spores can be used to assemble water-responsive materials with high energy densities and to create energy-harvesting devices that can generate electrical power from an evaporating body of water.
- Xi Chen
- , L. Mahadevan
- & Ozgur Sahin
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News & Views |
Cells made of silica
Treatment of mammalian cells with dilute silicic acid followed by heating forms silica replicas of the cell template, offering a way to preserve cell specimens and generate biocomposites for various applications.
- Jackie Y. Ying
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Article |
Controlling protein translocation through nanopores with bio-inspired fluid walls
Coating the walls of synthetic nanopores with fluid lipids slows down the translocation of proteins, eliminates non-specific binding and prevents clogging, thus offering a way to improve the performance of nanopore-based sensors.
- Erik C. Yusko
- , Jay M. Johnson
- & Michael Mayer